[Advances in studies on structure and pharmacological activities of natural tirucallane-type triterpenoids].

Zhongguo Zhong Yao Za Zhi

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050, China.

Published: August 2020

AI Article Synopsis

  • Tirucallane-type triterpenoids are a group of complex organic compounds made up of six isoprene units and belong to tetracyclic triterpenoids.
  • These compounds, although found in small amounts in nature, exhibit a variety of structures and possess significant bioactivities, including cytotoxicity, anti-inflammation, antioxidation, and anti-plasmin effects.
  • The paper reviews the origins, structures, and bioactivities of these triterpenoids over the past decade and discusses future research directions and potential applications.

Article Abstract

The tirucallane-type triterpenoids, composed of six isoprene units, belong to a group of tetracyclic triterpenoids. Although the naturally-derived tirucallane-type triterpenoids were found in a small amount, the kind of compounds showed various structures, which consist of apo-type, linear said-chain-type and cyclolike said-chain-type and broad bioactivities, such as cytotoxicity, anti-inflammation, antioxidation and anti-plasmin, etc. This paper summarized origins, structures and bioactivities of tirucallane-type triterpenoids in recent ten years. The future research and exploration of tirucallane-type triterpenoids were discussed and prospected.

Download full-text PDF

Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20200228.202DOI Listing

Publication Analysis

Top Keywords

tirucallane-type triterpenoids
16
tirucallane-type
5
triterpenoids
5
[advances studies
4
studies structure
4
structure pharmacological
4
pharmacological activities
4
activities natural
4
natural tirucallane-type
4
tirucallane-type triterpenoids]
4

Similar Publications

Article Synopsis
  • * Researchers isolated and characterized two triterpene isomers that co-crystallized in a consistent 67:33 ratio, confirming their structure using various advanced techniques.
  • * Four additional compounds were successfully isolated, with lutein and dyscusin C identified for the first time from this particular plant.*
View Article and Find Full Text PDF

Pharmacologically active small organic molecules derived from natural resources are prominent drug candidates due to their inherent structural diversity. Herein, we explored one such bioactive molecule, niloticin, which is a tirucallane-type triterpenoid isolated from the stem barks of (Wall.) Parker.

View Article and Find Full Text PDF

Boswellia carterii (BC) resins plants have a long historical background as a treatment for inflammation, as indicated by information originating from multiple countries. Twenty-seven diterpenoids have been identified in ethyl acetate and total methanol BC, comprising seventeen boscartins of the cembrane-type diterpenoids and ten boscartols of the prenylaromadendrane-type diterpenoids. Moreover, twenty-one known triterpenoids have also been found, encompassing nine tirucallane-type, six ursane-type, four oleanane-type, and two lupane-type.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!