AI Article Synopsis
- Acute lymphocytic leukemia (ALL) is a common cancer primarily affecting younger individuals, and its treatment often involves a combination of chemotherapy and corticosteroids.
- Corticosteroids can lead to hyperglycemia, and studies show that chemotherapy-induced diabetes can occur in 27.5% to 37% of ALL patients during treatment.
- Other factors contributing to hyperglycemia in ALL patients include leukemia cells affecting the pancreas and dysfunction of insulin-producing β cells due to certain chemotherapy drugs like L-asparagine.
Article Abstract
Acute lymphocytic leukemia (ALL) is one of the most common malignancies, especially in young people. Combination chemotherapy for ALL typically includes corticosteroids (Kantarjian et al., 2000). Hyperglycemia is a well-recognized complication of corticosteroids, and chemotherapy-induced diabetes (CID) is not uncommon (27.5%-37.0%) during the treatment of ALL (Hsu et al., 2002; Weiser et al., 2004; Alves et al., 2007). Besides the effect of corticosteroids, potential factors triggering hyperglycemia in ALL also include direct infiltration of the pancreas by leukemia cells and β cell dysfunction induced by chemotherapeutic agents such as L-asparagine (Mohn et al., 2004).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519633 | PMC |
| http://dx.doi.org/10.1631/jzus.B1900719 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy - a randomized controlled trial.
Front Neurol
December 2024
IIIrd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University Salzburg, Salzburg, Austria.
Background: Electrotherapy has been investigated in chronic pain and diabetic peripheral neuropathy, however prospective trials in patients with chemotherapy-induced peripheral neuropathy (CIPN) are scarce.
Methods: Fifty-one patients with CIPN ≥ grade 1 subsequent to receiving platinum- and/or taxane-based chemotherapy types were randomized to 8 weeks of high tone external muscle stimulation (HTEMS) or transcutaneous electrical nerve stimulation (TENS). The primary outcome were changes in the EORTC-QLQ-CIPN20 questionnaire.
Adjunctive nivolumab in combination with antibiotic therapy for the management of refractory melioidosis in a patient with metastatic breast cancer and chemotherapy-induced pancytopenia.
Trans R Soc Trop Med Hyg
January 2025
Department of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of higher Education, Manipal, Karnataka, India, 576104.
Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to multiple classes of antibiotics and primarily affects immunocompromised individuals, such as those with poorly controlled diabetes or malignancies. In this case, a 58-y-old female farmer with poorly controlled diabetes (HbA1c of 11.4%), metastatic breast cancer with chemotherapy-induced pancytopenia and disseminated melioidosis showed no improvement despite receiving antibiotics and supportive care.
View Article and Find Full Text PDFAcupuncture as an Adjunct Treatment in Stiff Person Syndrome.
Med Acupunct
October 2024
Department of Family Medicine, West Virginia University, Morgantown, West Virginia, USA.
Objective: Stiff person syndrome (SPS) is a rare neurological disorder. Treatments are limited, and non-pharmacologic therapies are recommended based on symptomatology. A G2P2002 post-menopausal 60-year-old female with hypertension, obesity, and type II diabetes, and SPS secondary to a paraneoplastic process cause by endometrioid ovarian adenocarcinoma who presented to acupuncture clinic seeking treatment for SPS and its sequela.
View Article and Find Full Text PDFPattern, causes and functional outcome of peripheral neuropathies in the Amazon region.
PLoS One
December 2024
Department of Neurology, Centre Hospitalier Andree Rosemon, Cayenne, French Guiana.
Article Synopsis
- The study analyzed 754 patients with peripheral neuropathies in French Guiana, highlighting the local factors influencing their severity.
- The most common causes were diabetes, chemotherapy-related issues, and Guillain-Barre syndrome, with significant associations found between infections and functional severity.
- It emphasizes that the region exhibits characteristics typical of both developed and developing countries, strongly linked to social health inequalities.
Remote organ cancer induces kidney injury, inflammation, and fibrosis and adversely alters renal function.
Am J Physiol Renal Physiol
December 2024
Department of Medicine, Division of Medical Oncology and Hematology, University of Louisville School of Medicine.
Approximately 30% of cancer patients experience kidney complications, which hinder optimal cancer management, imposing a burden on patients' quality of life and the healthcare system. The etiology of kidney complications in cancer patients is often attributed to oncological therapies. However, the direct impact of cancer on kidney health is underestimated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!