AI Article Synopsis
- The clinical features of xerostomia caused by immune checkpoint inhibitors (ICI) resemble those of Sjögren's syndrome (SS), but their immunohistological and serological characteristics differ.
- A case study of a 56-year-old male showed various imaging results indicating abnormal salivary gland conditions linked to ICI-induced xerostomia.
- Imaging findings included non-specific results on CT scans, unique patterns on MRI suggesting lymphocyte infiltration, and ultrasound revealing hypoechoic areas, indicating potential differences from typical SS presentations.
Article Abstract
The clinical features of xerostomia induced by immune checkpoint inhibitors (ICI) are similar to those of Sjögren's syndrome (SS), whereas the immunohistological and serological features are known to differ from those of SS. However, the radiologic imaging features of salivary glands are not yet well known. We report a case of a 56-year-old male patient diagnosed with ICI-induced xerostomia. The patient underwent various imaging examinations to investigate the condition of the salivary glands, which indicated the following: (1) less specific findings on contrast-enhanced computed tomography, (2) mixed with intermediate and low signal intensity on both T-weighted and fat-suppressed T-weighted magnetic resonance imaging and poor "salt and pepper" appearance on magnetic resonance sialography, and (3) multiple ovoid hypoechoic areas with hyperechoic bands without acute sialadenitis on ultrasound. These radiologic imaging findings suggested remarkable lymphocyte infiltration, which could be a characteristic of ICI-induced xerostomia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214578 | PMC |
| http://dx.doi.org/10.1007/s11282-020-00480-9 | DOI Listing |
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