and expression and association with the prognosis in esophageal squamous cell carcinoma.

We investigated whether and were related to esophageal squamous cell carcinoma (ESCC). ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyze and expression. The GSE120356 and GSE33810 datasets identified and as the candidates and and expression was downregulated in ESCC. and were positively correlated with ESCC. and expression could discriminate ESCC from normal tissue. Five-year overall survival was shorter in underexpressed patients, and expression level was related to 5-year overall survival. and expression were independent prognosis indicators in ESCC patients. Our findings shed new light on the clinical significance of and in ESCC carcinogenesis.