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RESOLUTION OF CALVARIAL HYPEROSTOSIS IN AFRICAN LION CUBS () AFTER VITAMIN A SUPPLEMENTATION.
J Zoo Wildl Med
March 2024
Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Two female (FL 1, FL 2) and one male (ML) 11-wk-old, intact, captive African lion cubs () were presented with a history of mild vestibular signs. Initial serum vitamin A concentrations were low (140 nmol/L) for ML. Calvarial hyperostosis was confirmed using computed tomography (CT) of the head and cervical vertebrae in each cub.
View Article and Find Full Text PDFBilateral compressive optic neuropathy and outer retinopathy due to optic canal hyperostosis in a child with isolated vitamin a deficiency.
Doc Ophthalmol
April 2023
Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Purpose: Vitamin A plays a crucial role in rod phototransduction, with deficient levels manifesting as night blindness. Animal models have demonstrated bone dysplasia in the setting of hypovitaminosis A. We present a rare case of bony overgrowth leading to bilateral compressive optic neuropathy, combined with outer retinopathy, in a paediatric patient secondary to isolated vitamin A deficiency.
View Article and Find Full Text PDFRetinoid-induced skeletal hyperostosis in disorders of keratinization.
Clin Exp Dermatol
December 2022
St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
For disorders of keratinization, topical treatment alone may be ineffective, and systemic retinoid therapy may be indicated. Treatment with systemic retinoids (acitretin, isotretinoin and alitretinoin) has been shown to be effective in reducing disease severity; however, potentially rare adverse effects (AEs) may occur, including hyperostotic skeletal changes. The true prevalence of this AE in adult patients administered life-long therapy is unknown.
View Article and Find Full Text PDFDiffuse idiopathic skeletal hyperostosis in a young woman treated with isotretinoin.
Reumatol Clin (Engl Ed)
March 2022
Department of Rheumatology, Hospital Son Llàtzer, Palma de Mallorca, Spain.
We present the case of a 36-year-old woman with diffuse idiopathic skeletal hyperostosis especially at cervical spine since she was 29 years old. The only relevant feature was the use of isotretinoin at regular doses in the past for severe acne.
View Article and Find Full Text PDFOsteochondroma formation is independent of heparanase expression as revealed in a mouse model of hereditary multiple exostoses.
J Orthop Res
October 2022
Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Article Synopsis
- * A study used a mouse model with genetic alterations to investigate the role of heparanase (Hpse), an enzyme that influences heparan sulfate levels, in osteochondroma development but found that removing Hpse did not significantly affect tumor formation.
- * Treatment with the retinoid Palovarotene successfully reduced osteochondroma formation in the mouse model, suggesting potential therapeutic options for managing HME, while indicating that heparanase might not be a key factor
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