Many tasks involve learning representations from matrices, and Non-negative Matrix Factorization (NMF) has been widely used due to its excellent interpretability. Through factorization, sample vectors are reconstructed as additive combinations of latent factors, which are represented as non-negative distributions over the raw input features. NMF models are significantly affected by latent factors' distribution characteristics and the correlations among them. And NMF models are faced with the challenge of learning robust latent factor. To this end, we propose to learn representations with an awareness of the semantic quality evaluated from the aspects of intra- and inter-factors. On the one hand, a Maximum Entropy-based function is devised for the intra-factor semantic quality. On the other hand, the semantic uniqueness is evaluated via inter-factor correlation, which reinforces the aim of semantic compactness. Moreover, we present a novel non-linear NMF framework. The learning algorithm is presented and the convergence is theoretically analyzed and proved. Extensive experimental results on multiple datasets demonstrate that our method can be successfully applied to representative NMF models and boost performances over state-of-the-art models.
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http://dx.doi.org/10.1016/j.neunet.2020.07.027 | DOI Listing |
J Phys Chem B
January 2025
INSERM U1248 Pharmacology & Transplantation, Univ. Limoges, CBRS, 2 Rue du Prof. Descottes, F-87000 Limoges, France.
Dry skin is a common condition that is experienced by many. Besides being particularly present during the cold season, various diseases exist all year round, leading to localized xerosis. To prevent it, the skin is provided with natural moisturizing factors (NMFs).
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January 2025
Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Changsha, China. Electronic address:
Background: Lactylation plays an important role in tumor progression. This study aimed to clarify the impact of lactylation on cancer-associated fibroblasts(CAFs).
Methods: Single-cell and bulk RNA sequence data, along with survival information, were obtained from TCGA and GEO datasets.
Front Immunol
January 2025
Department of Anesthesiology, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, China.
Background: Liver hepatocellular carcinoma (LIHC) ranks as the foremost cause of cancer-related deaths worldwide, and its early detection poses considerable challenges. Current prognostic indicators, including alpha-fetoprotein, have notable limitations in their clinical utility, thereby underscoring the necessity for discovering new biomarkers to improve early diagnosis and enable personalized treatment options.
Method: This investigation employed single-cell analysis techniques to identify stem cell-associated genes and assess their prognostic significance for LIHC patients, as well as the efficacy of immunotherapy, utilizing nonnegative matrix factorization (NMF) cluster analysis.
Transl Oncol
December 2024
Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China. Electronic address:
5-Methylcytosine (m5C) is a ubiquitous RNA modification that is closely related to various cellular functions. However, no studies have comprehensively demonstrated the role of m5C in hepatocellular carcinoma (HCC) progression. In this study, six pairs of HCC and adjacent tissue samples were subjected to methylated RNA immunoprecipitation sequencing to identify precise m5C loci.
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December 2024
School of Computer Science and Engineering, The Hebrew University of Jerusalem.
Motivation: Non-negative Matrix Factorization (NMF) is a powerful tool often applied to genomic data, to identify non-negative latent components that constitute linearly mixed samples. It is useful when the observed signal combines contributions from multiple sources, such as cell types in bulk measurements of heterogeneous tissue. NMF accounts for two types of variation between samples-disparities in the proportions of sources and observation noise.
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