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CART (Cocaine- and Amphetamine-Regulated Transcript): A New Identified Intrafollicular Mediator in Ovulation Induction Protocols.
Biomedicines
November 2024
Fertility Institute-Assisted Reproduction Unit, Paster 15, 11528 Athens, Greece.
Background/objectives: This study investigates the relationship between cocaine- and amphetamine-regulated transcript (CART) expression, leptin, and hormone profiles-specifically progesterone, testosterone, androstenedione, estradiol, follicle-stimulating hormone (FSH), and human chorionic gonadotropin (hCG)-across four distinct ovulation induction protocols (HMG, HMG/hCG, rFSH, and rFSH/hCG). It also investigates the relationship between follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphisms, CART expression, and in vitro fertilization (IVF) results, with the goal of better understanding how CART and FSHR polymorphisms affect ovarian response and oocyte quality.
Methods: Data were obtained from 94 women who underwent controlled ovarian stimulation (COS) as part of their IVF therapy.
Left ventricular end-diastolic pressure response to spinal anaesthesia in euvolaemic vascular surgery patients.
J Clin Monit Comput
September 2024
School of Health Sciences, Faculty of Medicine, Second Department of Surgery - Division of Vascular Surgery, Aristotle University of Thessaloniki, "G. Gennimatas" Hospital, Thessaloniki, Greece.
Purpose: Regional anaesthesia techniques provide highly effective alternative to general anaesthesia. Existing evidence on the effect of spinal anaesthesia (SA) on cardiac diastolic function is scarce. This study aimed to evaluate the effects of a single-injection, low-dose SA on left ventricular end-diastolic pressures (LVEDP) using echocardiography in euvolaemic patients undergoing elective vascular surgery.
View Article and Find Full Text PDFChemotherapy response score as a predictor of survival in ovarian cancer patients.
Eur J Obstet Gynecol Reprod Biol
May 2024
1(st) Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.
Article Synopsis
- The study investigates the impact of the chemotherapy response score (CRS) on survival rates in ovarian cancer patients, comparing those who received debulking surgery to those who did not.
- Significant differences in progression-free survival (PFS) and overall survival (OS) were found among CRS-stratified groups, with all surgical patients faring better than non-surgical ones.
- The findings suggest that CRS is a key factor for predicting survival outcomes and could inform personalized treatment strategies for ovarian cancer patients.
Microarray evidence that 8-cell human embryos express some hormone family members including oxytocin.
J Assist Reprod Genet
February 2024
Bedford Research Foundation, Bedford, MA, USA.
Objective: This study is to discover hormone pathways active in early cleaving human embryos.
Methods: A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency.
Results: Over half of the 152 hormones and receptors were silent on the arrays of all cell types, and more were detected at high or moderate levels on the 8-cell arrays than on the pluripotent cell or fibroblast arrays.
Chemotherapy Response Score in Ovarian Cancer Patients: An Overview of Its Clinical Utility.
J Clin Med
March 2023
Division of Gynecologic Oncology, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 10679 Athens, Greece.
The chemotherapy response score has been developed over the last few years as a predictive index of survival outcomes for patients with advanced-stage epithelial ovarian cancer undergoing interval debulking surgery. While its importance in predicting patients at risk of developing recurrences earlier seems to be important, its accuracy in determining patients with a shorter overall survival remains arbitrary. Moreover, standardization of the actual scoring system that was initially developed as a 6-tiered score and adopted as a 3-tiered score is still needed, as several studies suggest that a 2-tiered system is preferable.
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