AI Article Synopsis
- Wound healing is vital for repairing tissue and preventing infections, but current treatments often fall short, especially against antibiotic-resistant bacteria.
- Researchers developed ABgel, an injectable hydrogel containing acidic fibroblast growth factor (aFGF) and bacteriophage, aimed at enhancing wound regeneration and fighting bacteria.
- ABgel's composition allows it to mimic skin, effectively combat antibiotic-resistant E. coli, and promote skin regeneration in mice, showcasing its potential as a versatile wound dressing.
Article Abstract
Wound healing is a complex process involved in repairing tissue damage and preventing infection. However, there is a lack of appropriate treatment solutions that can simultaneously promote tissue repair and protect againstbacteria, especially antibiotic-resistant bacteria. In this study, we have developed an injectable hydrogel encapsulating acidic fibroblast growth factor (aFGF) and bacteriophage, termed as ABgel, for combating antibiotic-resistant bacteria and enhancing wound regeneration. ABgel is composed of oxidized sodium alginate (OSA), gelatin and hyaluronic acid (HA), and can rapidly form hydrogel with an elastic modulus of 13 kPa, which mimics the skin tissues. In addition, ABgel can effectively load and stabilize bacteriophage and aFGF, allowing for preventing bacterial infections and improving regeneration of damaged dermal tissues. In vitro studies demonstrate that ABgel exhibits enormous antibacterial activity against antibiotic-resistant E. coli and enhanced angiogenetic activity. Importantly, ABgel can promote skin regeneration and prevent bacterial infections in mice, thereby promoting wound healing process. Therefore, ABgel represents a decent bioactive engineered hydrogel dressing with a broad application potential.
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| http://dx.doi.org/10.1016/j.ijbiomac.2020.08.247 | DOI Listing |
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