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Effective Management of Severe Epidermal Growth Factor Receptor Inhibitors-Induced Papulopustular Eruption With Low-Dose Isotretinoin and Corticosteroids.
Cureus
November 2024
Oncologic Dermatology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Epidermal growth factor receptor inhibitors (EGFRi) are approved for treating various cancers. Given that EGFR signaling is crucial for normal skin growth and repair, inhibiting this pathway can disrupt skin homeostasis and integrity. Although generally well tolerated, molecularly targeted therapies can lead to skin-related adverse effects that significantly impact patients' quality of life, often resulting in treatment interruptions.
View Article and Find Full Text PDFLichen Planus Pigmentosus and Vitiligo in a 61-Year-Old Filipino Man: Case Report.
JMIR Dermatol
November 2024
Department of Dermatology, De La Salle Medical and Health Sciences Institute, Dasmariñas, Cavite, Philippines.
Article Synopsis
- - Pigmentary disorders like Lichen planus pigmentosus (LPP) and vitiligo can lead to significant cosmetic concerns and psychosocial stress for patients.
- - A 61-year-old man with LPP developed vitiligo and was successfully treated with low-dose isotretinoin and topical tacrolimus ointment.
- - The coexistence of LPP and vitiligo might be explained by an autoimmune process affecting skin pigmentation called melanocytorrhagy.
Comment on 'Low-dose isotretinoin for the management of rosacea: A systematic review and meta-analysis'.
J Eur Acad Dermatol Venereol
November 2024
Department of Paediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Management of human epidermal growth factor receptor inhibitors-related acneiform rash: A position paper based on the first Europe/USA Delphi consensus process.
J Eur Acad Dermatol Venereol
October 2024
Oncodermatology Department, Cancer University Institute, Toulouse Oncopole, Toulouse, France.
Background: There is a need for unified guidance in the management of acneiform rash induced by epidermal growth factor receptor inhibitors (EGFRi) among dermatologists.
Objective: To establish unified international guidelines for the management of acneiform rash caused by EGFR inhibitors, based on an experts' Delphi consensus.
Methods: The initiative was led by five members of the European Academy of Dermatology and Venereology Task Force 'Dermatology for Cancer Patients' who developed a questionnaire that was circulated to a group of 32 supportive oncodermatology experts in Europe, Canada, Argentina, the US States and Asia.
Serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.
Caspian J Intern Med
September 2024
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Article Synopsis
- Acne vulgaris is a common skin condition and isotretinoin is the most effective treatment for severe cases, but it may cause changes in serum lipid levels.
- A study involving 65 adolescents and adults on a low dose of isotretinoin for 120 days found significant increases in cholesterol and LDL levels, but no major changes in HDL and triglycerides.
- While isotretinoin can be used with minimal immediate concerns about lipid changes, long-term use should be monitored carefully to manage potential risks.
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