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African-Colombian woman with preeclampsia and high-risk APOL1 genotype: A case report.
Medicine (Baltimore)
November 2024
Departamento de Ciencias Basicas Medicas, Facultad de Salud, Universidad Icesi, Cali, Colombia.
Article Synopsis
- Preeclampsia is a serious pregnancy complication that mainly affects Black women, and genetic factors like APOL1 G1 and G2 alleles contribute to this increased risk.
- A 17-year-old African Colombian patient experienced severe preeclampsia symptoms, including convulsions and high blood pressure, along with a genetic predisposition identified through testing.
- Treatment included medication to manage hypertension and seizures, leading to the decision to terminate the pregnancy via cesarean section, and highlighting the need to consider genetic factors in managing preeclampsia in similar cases.
Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases.
Pain Res Manag
October 2024
Department of Hospice Care, Shengjing Hospital of China Medical University, Shenyang 110022, China.
Cancer-related pain is a pervasive symptom affecting the quality of life in patients with malignant tumors. For those with refractory pain, palliative sedation combined with pain management is recommended. Dexmedetomidine (DEX), known for its unique "awake sedation" effect, remains relatively unexplored when used in conjunction with patient-controlled analgesia (PCA) for terminal-stage cancer patients.
View Article and Find Full Text PDFInsulin Stabilization Designs for Enhanced Therapeutic Efficacy and Accessibility.
Acc Chem Res
November 2024
Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California 94305, United States.
Article Synopsis
- Insulin has been essential for diabetes treatment since 1921, but its stability is compromised by temperature, transport, and storage challenges, requiring strict cold-chain management that limits access in low-income areas.
- Despite advancements in insulin formulations, current treatments still present difficulties for patients, necessitating safer and more user-friendly therapies to improve outcomes.
- Recent research has led to the creation of novel stable insulin analogs and miniaturized formulations that maintain bioactivity while enhancing stability and absorption rates, addressing both stability and usability issues in insulin therapies.*
Effectiveness and safety of Perampanel in refractory status epilepticus: a case series.
Neurol Sci
October 2024
Department of Neurosciences, AOU "San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Introduction: Perampanel is a selective non-competitive antagonist of AMPA receptors, and the first agent of this class to become available for the treatment of epilepsy. It could be a useful tool for treatment of refractory status epilepticus (RSE).
Methods: We describe a series of eight RSE cases treated with Perampanel.
Right-to-left-shunts in patients scheduled for neurosurgical intervention in semi-sitting position - a literature review based on two case scenarios.
BMC Anesthesiol
October 2024
Medical Faculty Heidelberg, Department of Anesthesiology, Heidelberg University, Heidelberg, Germany.
Article Synopsis
- Neurosurgery in a semi-sitting position has benefits for some procedures, but it can increase the risk of venous air embolism, especially in patients with specific heart defects.
- Two young patients with congenital heart defects were evaluated using transesophageal echocardiography to identify potential right-to-left shunts before undergoing surgery for vestibular schwannoma.
- Perioperative echocardiography is crucial for detecting potential complications and determining if a semi-sitting position is safe, but surgical teams must be prepared for rapid response if significant air entry occurs.
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