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Genetic Code Expansion: Recent Developments and Emerging Applications.
Chem Rev
December 2024
Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines, Key Laboratory of Quantitative Synthetic Biology, Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China.
The concept of genetic code expansion (GCE) has revolutionized the field of chemical and synthetic biology, enabling the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins, thus opening new avenues in research and applications across biology and medicine. In this review, we cover the principles of GCE, including the optimization of the aminoacyl-tRNA synthetase (aaRS)/tRNA system and the advancements in translation system engineering. Notable developments include the refinement of aaRS/tRNA pairs, enhancements in screening methods, and the biosynthesis of noncanonical amino acids.
View Article and Find Full Text PDFEnvironment-Organism Feedbacks Drive Changes in Ecological Interactions.
Ecol Lett
January 2025
Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Ecological interactions are foundational to our understanding of community composition and function. While interactions are known to change depending on the environmental context, it has generally been assumed that external environmental factors are responsible for driving these dependencies. Here, we derive a theoretical framework which instead focuses on how intrinsic environmental changes caused by the organisms themselves alter interaction values.
View Article and Find Full Text PDFCritical Role of Nanomaterial Mechanical Properties in Drug Delivery, Nanovaccines and Beyond.
Adv Mater
December 2024
School of Chemical Engineering, The University of Adelaide, North Terrace, South Australia, 5005, Australia.
Nanomaterials have become essential in the daily lives, finding applications in food, skincare, drugs, and vaccines. Traditionally, the surface chemistry of nanoparticles (NPs) is considered the key factor in determining their interactions with biological systems. However, recent studies have shown that the mechanical properties of nanomaterials are equally important in regulating nano-bio interactions, though they have often been overlooked.
View Article and Find Full Text PDFChronic Complications of Diabetes Mellitus.
West Afr J Med
August 2024
Iwosan-Lagoon Hospital, 17 Bourdilon Road. Ikoyi. Lagos State. Nigeria.
Background: This review article describes the chronic complications of diabetes mellitus (DM). The chronic complications of DM are diverse, often progressive and difficult to manage or reverse.
Objective: The aim of this review is to highlight the current concepts in the pathogenic mechanisms of the chronic complications of diabetes mellitus, with a view to educate doctors and specialists on the management of these problems.
Research progress and treatment status of malignant ascites.
Front Oncol
December 2024
Department of Oncology, Guang'anmen Hospital Jinan Hospital (Jinan Hospital of Traditional Chinese Medicine), Jinan, China.
Malignant ascites (MA), a common and serious complication of various cancers in the abdominal cavity, originates from the extensive infiltration, metastasis, and growth of cancer cells in or on the abdominal cavity, leading to abnormal accumulation of fluid in the abdominal cavity and the formation of MA. MA seriously reduces the quality of life of cancer patients, shortens their survival period, and generally has a poor prognosis. Modern medicine has developed various strategies for the treatment of MA, including targeted supportive treatment, diuretic treatment, abdominal paracentesis, surgical intervention, and intraperitoneal administration therapy.
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