In this study, we developed a catalytic system for the C-alkylation of a methyl group on -heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl] (Cp*: η-pentamethylcyclopentadienyl) combined with potassium -butoxide and 18--6-ether as the catalyst precursor.
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| http://dx.doi.org/10.1021/acs.orglett.0c02635 | DOI Listing |
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