Baicalensines A and B, Two Isoquinoline Alkaloids from the Roots of .

Baicalensines A () and B () were isolated from the roots of and structurally characterized using spectroscopic data, C NMR calculations, and the CASE algorithm. Compound , representing a new class of alkaloid dimers, contains berberine conjugated to a ring-opened isoquinoline. Compound is the first reported natural benzylisoquinoline bearing a formyl group at C-3. Plausible biosynthetic pathways are proposed. Compound exerted moderate cytotoxicity against the Caco-2 and HL-60 cell lines.