Microdosimetry has been traditionally performed through gaseous proportional counters, although in recent years different solid-state microdosimeters have been proposed and constructed for this task. In this paper, we analyze the response of solid-state devices of micrometric size with no intrinsic gain developed by CNM-CSIC (Spain). There are two major aspects of the operation of these devices that affect the reconstruction of the probability distributions and momenta of stochastic quantities related to microdosimetry. For micrometric volumes, the drift and diffusion of the charge carriers gives rise to a partial charge collection efficiency in the peripheral region of the depleted volume. This effect produces a perturbation of the reconstructed pulse height (i.e. imparted energy) distributions with respect to the actual microdosimetric distributions. The relevance of this deviation depends on the size, geometry and operating conditions of the device. On the other hand, the electronic noise from the single-event readout set-up poses a limit on the minimum detectable lineal energy when the microdosimeter size is reduced. This article addresses these issues to provide a framework on the physical constraints for the design and operation of solid-state microdosimeters.
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http://dx.doi.org/10.1088/1361-6560/ab87fa | DOI Listing |
Patient Saf Surg
January 2025
NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Background: Meniscal surgery is one of the most frequent orthopaedic procedures performed worldwide. There is a wide range of possible treatment errors that can occur following meniscal surgery. In Norway, patients subject to treatment errors by hospitals and private institutions can file a compensation claim free of charge to the Norwegian System of Patient Injury Compensation (NPE).
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January 2025
Bureau de L'Organisation Mondiale de La Santé (OMS), Niamey, Niger.
Background: Recently, a total of 74 circulating vaccine-derived poliovirus (cVDPV) outbreaks were detected in 39 countries, with 672 confirmed Acute Flaccid Paralysis (AFP) cases identified in 27 countries. Despite progress, Niger experienced cVDPV outbreaks in 2018, highlighting the importance of maintaining AFP surveillance as a tool for polio eradication. This analysis aims to comprehensively assess AFP surveillance trends, patterns, and challenges in Niger, offering insights for public health initiatives in conflict-affected contexts.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, United States.
Modification of silica interfaces by covalent attachment of functional ligands is a primary means of controlling the interfacial chemistry of porous silicas used in separations, environmental cleanup, and biosensing. Recently, modification of hydrophobic, -alkyl-silane-functionalized interfaces has been achieved through self-assembly of zwitterionic phospholipids or mixed-charged surfactants to form "hybrid bilayers", producing interfaces that mimic lipid-bilayer partitioning and provide shape-selective partitioning of aromatic hydrocarbons. Charged headgroups, however, introduce electrostatic interactions that strongly influence the retention of ionizable solutes and require careful control over pH and ionic strength in the solution phase.
View Article and Find Full Text PDFDrugs R D
January 2025
Quality Evaluation Team, Samsung Bioepis Co., Ltd, Incheon, South Korea.
Background: SB17 is being developed as a biosimilar to ustekinumab reference product (RP), a human monoclonal antibody (IgG1 kappa immunoglobulin) that binds to the common p40 subunit of cytokines interleukin (IL)-23 and IL-12. Binding to this subunit prevents interaction with their receptor, resulting in modulation in the immune system responses that play a key role in inflammatory disease.
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PLoS One
January 2025
School of Power and Mechanical Engineering, Wuhan University, Wuhan, China.
The prevailing trend in industrial equipment development is integration, with pipelines as the lifeline connecting system components. Given the often harsh conditions of these industrial equipment pipelines, leakage is a common occurrence that can disrupt normal operations and, in severe cases, lead to safety accidents. Early detection of even minor drips at the onset of leakage can enable timely maintenance measures, preventing more significant leaks and halting the escalation of pipeline failures.
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