AI Article Synopsis
- Lipocalin 2 is a key protein associated with breast cancer and a target for treatment.
- Researchers evaluated 10 drug analogues derived from Docetaxel to enhance their binding efficiency with Lipocalin 2.
- The findings highlight potential new drug candidates that could improve treatment options for breast cancer.
Article Abstract
Lipocalin 2 (Lcn2, also called as neutrophil gelatinase-associated lipocalin) is a member of the lipocalin family and a known target for breast cancer. Therefore, it is of interest to use Docetaxel as a scaffold to design molecules with improved efficiency from naturally derived phytochemicals. We document 10 analogues (4Deacetyltaxol, 7Acetyltaxol, Cabazitaxel, Cephalomannine, Docetaxal, Deacetyltaxol, Docetaxeltrihydrate, Ortataxel, Paclitaxel, Taxoline) having optimal binding with Lipocalin 2 in comparison with Docetaxel. This data is highly useful for consideration in the design and development of drugs for breast cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452746 | PMC |
| http://dx.doi.org/10.6026/97320630016438 | DOI Listing |
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