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Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.
PLoS Biol
January 2025
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as metabolic zonation. R-spondin3 (Rspo3), a bioactive protein promoting the Wnt signaling pathway, regulates metabolic features especially around hepatic central veins. However, the functional impact of hepatic metabolic zonation, regulated by the Rspo3/Wnt signaling pathway, on whole-body metabolism homeostasis remains poorly understood.
View Article and Find Full Text PDFMicroencapsulated Escape Lysine with Tannin as an Adjuvant in Sheep Diets.
Vet Sci
January 2025
Graduate Program in Animal Science and Health, Federal University of Campina Grande, Patos 58708110, Brazil.
The use of escape protein, which is absorbed in the small intestine, can improve the production of ruminant animals because it meets their protein requirements better. This study hypothesized that wax lipid matrices are effective encapsulants for escape lysine in ruminants and tested tannin extract as an adjuvant. Forty intact male Santa Ines × Dorper sheep (~4 months old, BW 23 ± 1.
View Article and Find Full Text PDFEpigenetics in Skin Homeostasis and Ageing.
Epigenomes
January 2025
Department of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
The skin, the largest organ of the human body, plays numerous essential roles, including protection against environmental hazards and the regulation of body temperature. The processes of skin homeostasis and ageing are complex and influenced by many factors, with epigenetic mechanisms being particularly significant. Epigenetics refers to the regulation of gene expression without altering the underlying DNA sequence.
View Article and Find Full Text PDFStevioside mitigates metabolic dysregulation in offspring induced by maternal high-fat diet: the role of gut microbiota-driven thermogenesis.
Gut Microbes
December 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Maternal obesity poses a significant threat to the metabolic profiles of offspring. Microorganisms acquired from the mother early in life critically affect the host's metabolic functions. Natural non-nutritive sweeteners, particularly stevioside (STV), play a crucial role in reducing obesity and affecting gut microbiota composition.
View Article and Find Full Text PDFDexmedetomidine-associated hypothermia in critical trauma: A case report and literature analysis.
Medicine (Baltimore)
January 2025
Department of Trauma Surgery, Chungbuk National University Hospital, Cheongju, Republic of Korea.
Rationale: Hypothermia, defined as a core body temperature below 35°C, is a common and serious complication in severe trauma patients, often worsened by hemorrhage and medical interventions. Dexmedetomidine, an α2-adrenergic agonist used for sedation in intensive care units, has known thermoregulatory effects; however, its association with hypothermia in trauma patients remains insufficiently explored.
Patient Concerns: A 40-year-old male with severe polytrauma from a motor vehicle accident presented in distress, with hypotension, tachycardia, and a baseline temperature of 35.
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