AI Article Synopsis
- Prohibitins (PHBs) are important proteins in mitochondria, classified into two types: PHB1 and PHB2, which work together in regulating mitochondrial structure and function.
- They interact to form heterodimers in the mitochondrial inner membrane.
- Research indicates that Plasmodium falciparum also has these proteins (Pf PHB1 and Pf PHB2), which might interact in a similar way, suggesting a potential role in maintaining mitochondrial function in this organism.
Article Abstract
Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane. Plasmodium falciparum has orthologues of PHB1 and PHB2 in its genome, and their role is unclear. Here, by homology modelling and yeast two-hybrid analysis, we show that putative Plasmodium PHBs (Pf PHB1 and Pf PHB2) interact with each other, which suggests that they could form supercomplexes of heterodimers in Plasmodium, the functional form required for optimum mitochondrial function.
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