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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines.
Nat Commun
January 2025
Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Polioviruses have caused crippling disease in humans for centuries, prior to the successful development of vaccines in the mid-1900's, which dramatically reduced disease prevalence. Continued use of these vaccines, however, threatens ultimate disease eradication and achievement of a polio-free world. Virus-like particles (VLPs) that lack a viral genome represent a safer potential vaccine, although they require particle stabilization.
View Article and Find Full Text PDFForestry bill threatens the Amazon's water cycle.
Science
January 2025
Escola de Artes, Ciências, e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil.
Strange features are no better than no features: predator recognition by untrained birds.
Anim Cogn
January 2025
Department of Zoology, Faculty of Science, University of South Bohemia, Branišovská 1760, České Budějovice, 370 05, Czech Republic.
Predator recognition is essential for prey survival, allowing for appropriate antipredator strategies. Some bird species, such as the red-backed shrike (Lanius collurio), distinguish not only between predators and non-threatening species but also between different predator species. Earlier studies have identified general predator "key features", especially beak shape and talons, as critical for predator recognition.
View Article and Find Full Text PDFBridging the Vaccination Equity Gap: A Community-Driven Approach to Reduce Vaccine Inequities in Polio High-Risk Areas of Pakistan.
Vaccines (Basel)
November 2024
Centre of Excellence in Women and Child Health, Aga Khan University, Karachi 74800, Pakistan.
Immunization saves millions of lives, and globally, vaccines have significantly contributed to reducing mortality and morbidity due to more than 20 life-threatening illnesses. However, there are considerable disparities in vaccination coverage among countries and within populations. This study evaluates the reduction in disparities in vaccination coverage across various socio-economic groups by adopting an integrated community-engagement approach combined with maternal and child health services through mobile health camps.
View Article and Find Full Text PDFDevelopment and validation of genome-informed and multigene-based qPCR and LAMP assays for accurate detection of : a critical quarantine pathogen threatening the potato industry.
Microbiol Spectr
January 2025
Department of Plant and Environmental Protection Sciences, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
one of the most aggressive pectinolytic phytopathogens, causes blackleg disease in potatoes, resulting in significant economic losses and adversely impacting one of the world's most important food crops. The diagnostics methods are critical in monitoring the latent infection for international trade of potato seed tubers and in implementation of control strategies. Our study employed a whole-genome comparative approach, identifying unique target gene loci (LysR and TetR family of transcriptional regulators gene regions) and designing loop-mediated isothermal amplification (LAMP) and a multi-gene-based multiplex TaqMan qPCR assays for specific detection and differentiation of .
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