AI Article Synopsis
- Baicalein is shown to have anti-cancer properties, but its effectiveness against cervical cancer (CC) is influenced by lncRNA SNHG1, which reduces its tumor-suppressive capabilities.
- The study reveals that SNHG1 negatively impacts the effects of baicalein by altering the miR-3127-5p/FZD4/Wnt/β-catenin signaling pathway.
- SNHG1's role as a modulator suggests it could be targeted for therapies aimed at enhancing the anti-cancer effects of baicalein in cervical cancer.
Article Abstract
Baicalein exhibits anti-cancer roles in several cancers. However, the factors influencing the antitumorigenic efficiencies of baicalein in CC remain largely unclear. Here, we provide convincing evidences that lncRNA SNHG1 attenuates the tumor-suppressive roles of baicalein in CC cell viability, apoptosis, migration, and CC tumor growth. This study further demonstrates that the influences of SNHG1 in the antitumorigenic process of baicalein are achieved through modulating the miR-3127-5p/FZD4Wnt/β-catenin axis. SNHG1 attenuates the repressive role of baicalein on Wnt/β-catenin. Therefore, SNHG1 is a novel modulator of the tumor-suppressive roles of baicalein and SNHG1 represents a therapeutic intervention target to reinforce the tumor-suppressive roles of baicalein in CC.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798002 | PMC |
| http://dx.doi.org/10.1177/1535370220955139 | DOI Listing |
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