An efficient three-component domino or one-pot strategy has been developed for the synthesis of medicinally important benzothiophene and benzothiopheno[2,3-]azepinedione derivatives for the first time. Amine-promoted selective cleavage of C-S bond of thioisatin is the key step in this process. The reported methodology benefits from environmentally friendly solvent (HO), wide substrate scope, good functional group tolerance, and high reaction yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.0c01505 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construction of Benzothiophene or Benzothiopheno[2,3-]azepinedione Derivatives via Three-Component Domino or One-Pot Sequences.
J Org Chem
October 2020
Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion; Tianjin Key Laboratory of Drug Targeting and Bioimaging, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China.
An efficient three-component domino or one-pot strategy has been developed for the synthesis of medicinally important benzothiophene and benzothiopheno[2,3-]azepinedione derivatives for the first time. Amine-promoted selective cleavage of C-S bond of thioisatin is the key step in this process. The reported methodology benefits from environmentally friendly solvent (HO), wide substrate scope, good functional group tolerance, and high reaction yields.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!