AI Article Synopsis
- Actin and non-muscle myosins are crucial for guiding growth cones and promoting the outgrowth of neurites, which are essential for neuron development.
- Recent studies have identified new roles for non-muscle myosin in axons and dendritic spines, suggesting they help organize and maintain the structure of these neuron parts.
- The review focuses on summarizing recent discoveries about where myosin is found and how it functions in these areas, as well as exploring how actomyosin is involved in their roles and the signaling pathways that regulate them.
Article Abstract
Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structural properties of dendritic spines, the size and location of axon initial segment and axonal diameter are emerging research topics. In this review, we aim to summarize recent findings involving myosin localization and function in these compartments and to discuss possible roles for actomyosin in their function and the signaling pathways that control them.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565476 | PMC |
| http://dx.doi.org/10.3390/cells9092006 | DOI Listing |
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