Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study.

Alexa Hughes Jessica Dahmus Gloriany Rivas Breianna Hummer Jeremy R Chen See Justin R Wright Regina Lamendella Kathryn H Schmitz Christopher Sciamanna Mack Ruffin Andrew D Patterson Rohit Loomba Jonathan G Stine

Clin Gastroenterol Hepatol

Division of Gastroenterology and Hepatology, Department of Medicine, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Department of Public Health Sciences, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Cancer Institute, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania; Liver Center, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania. Electronic address:

Published: August 2021

Nonalcoholic fatty liver disease is the leading cause of liver disease worldwide and can progress to nonalcoholic steatohepatitis (NASH) through physical inactivity and gut dysbiosis. Exercise training reverses gut dysbiosis in non-NASH persons with obesity and in NASH animal models. Consequently, we conducted a proof-of-concept study investigating the effect of exercise training on gut dysbiosis in NASH patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9067391	PMC
http://dx.doi.org/10.1016/j.cgh.2020.08.063	DOI Listing

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