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Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells.
Allergy Asthma Clin Immunol
April 2021
Department of Dermatovenereology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, China.
Background: IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chronic spontaneous urticarial (CSU). Our study aims to explore the inhibited role of IL-35 in HMC-1.
View Article and Find Full Text PDFHistamine down-regulates the FCERI α-chain expression in human IL-4-activated M2 macrophages.
Allergy
April 2021
Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
IL-33 mediated amplification of allergic response in human mast cells.
J Recept Signal Transduct Res
August 2019
Department of Biotechnology, School of Bio-Engineering, SRM Institute of Science and Technology, Chennai, India.
IL-33 is a pro-inflammatory cytokine that is involved in the development of chronic inflammatory diseases and the initiation of allergic inflammation in response to pathogens and acts an alarmin. Present study aims to explore the IL-33 mediated effects of histamine induced allergic inflammation in human mast cells. In this study, cord blood derived CD34+ mast cells and HMC-1 cells were primed with IL-33 followed by the stimulation with histamine.
View Article and Find Full Text PDFTreatment of urticaria: a clinical and mechanistic approach.
Curr Opin Allergy Clin Immunol
August 2019
Department Medicine, The Medical University of South Carolina, Charleston, South Carolina, USA.
Purpose Of Review: This manuscript describes the recommended therapy of chronic spontaneous urticaria based on our understanding of the pathogenesis of hive formation. Thus, the mechanism of action of each medication is elaborated in addition to a discussion of clinical utility.
Recent Findings: The main drugs are antihistamines, omalizumab, and cyclosporine with a success rate of 40-55, 65-80, and 70-80%, respectively.
Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways.
Sci Rep
September 2017
Department of Anatomy and Histology and Embryology, Yanbian University Medical College, Yanji, 133002, P.R. China.
Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in in vitro and in vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effect in vivo. Various signaling pathway proteins in mast cell were examined.
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