Objective: The objective of the scoping review is to map the range of methodologies used to undertake evidence synthesis aimed at determining barriers and enablers in health care.
Introduction: The number of evidence synthesis studies focusing on identifying factors that support/facilitate (act as "enablers") or impede (act as "barriers") implementation of best practice in health care has significantly increased as researchers and clinicians strive to understand the evidence-practice gap. There is currently no consensus on the evidence synthesis approach for such topics, with the methods for analyzing or synthesizing results from barrier and enabler studies varying across existing evidence reviews.
Inclusion Criteria: This scoping review will consider various evidence synthesis approaches that identify barriers and enablers in health care. The review will only consider evidence synthesis approaches that describe their methods (e.g. systematic reviews or scoping reviews rather than literature reviews). Barriers and enablers could be at different levels of the health system, including consumers of care, health practitioners, health organization, policy makers, and the community. The scoping review will focus on the methodological aspects or processes related to the review of primary studies on barriers and/or enablers.
Methods: The proposed scoping review will be conducted in accordance with JBI methodology for scoping reviews. Studies will be searched in PubMed (NLM), Embase (Elsevier), CINAHL (EBSCOhost), PsycINFO (Ovid), Cochrane Database of Systematic Reviews, JBI Evidence Synthesis, and EPPI-Centre Systematic Reviews. Data extraction will be undertaken using a purpose-built data extraction form. A narrative summary will accompany the tabulated data/figures, with a view to proposing recommendations related to the methodology for undertaking evidence synthesis of barrier and enabler studies.
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http://dx.doi.org/10.11124/JBIES-20-00177 | DOI Listing |
Environ Microbiol
January 2025
Department of Biology, University of Oxford, Oxford, UK.
Rhizobia and legumes form a symbiotic relationship resulting in the formation of root structures known as nodules, where bacteria fix nitrogen. Legumes release flavonoids that are detected by the rhizobial nodulation (Nod) protein NodD, initiating the transcriptional activation of nod genes and subsequent synthesis of Nod Factors (NFs). NFs then induce various legume responses essential for this symbiosis.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
January 2025
Department of Hepato-Biliary-Pancreatic Surgery, General Surgery, Huadong Hospital, Fudan University, Shanghai, 200040, PR China.
Purpose: Glucose starvation induces the accumulation of disulfides and F-actin collapse in cells with high expression of SLC7A11, a phenomenon termed disulfidptosis. This study aimed to confirm the existence of disulfidptosis in pancreatic ductal adenocarcinoma (PDAC) and elucidate the role of Cancer Susceptibility 8 (CASC8) in this process.
Methods: The existence of disulfidptosis in PDAC was assessed using flow cytometry and F-actin staining.
Stem Cell Res Ther
January 2025
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, P. R. China.
Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.
View Article and Find Full Text PDFCell Death Dis
January 2025
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Immunology, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Glioblastoma (GBM) is the most common malignant primary brain cancer with poor prognosis due to the resistant to current treatments, including the first-line drug temozolomide (TMZ). Accordingly, it is urgent to clarify the mechanism of chemotherapeutic resistance to improve the survival rate of patients. In the present study, by integrating comprehensive non-coding RNA-seq data from multiple cohorts of GBM patients, we identified that a series of miRNAs are frequently downregulated in GBM patients compared with the control samples.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!