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Conformational dynamics of the membrane protein of MERS-CoV in comparison with SARS-CoV-2 in ERGIC complex.
J Biomol Struct Dyn
January 2025
College of Applied Medical Sciences, lmam Abdulrahman Bin Faisal University (lAU), Dammam, Saudi Arabia.
The present study explores the conformational dynamics of the membrane protein of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within the Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) complex using an all-atomistic molecular dynamics simulation approach. Significant structural changes were observed in the N-terminal, C-terminal, transmembrane, and beta-sheet sandwich domains of the MERS-CoV membrane protein. This study also highlights the structural similarities between the MERS-CoV and the SARS-CoV-2 membrane proteins, particularly in how both exhibit a distinct kink in the transmembrane helix caused by aromatic residue-lipid interactions.
View Article and Find Full Text PDFExploring pyrazolines as potential inhibitors of NSP3-macrodomain of SARS-CoV-2: synthesis and in silico analysis.
Sci Rep
January 2025
Bioinformatics Centre, Savitribai Phule Pune University, Pune, Maharashtra, 411007, India.
COVID-19 has proved to be a global health crisis during the pandemic, and the emerging JN.1 variant is a potential threat. Therefore, finding alternative antivirals is of utmost priority.
View Article and Find Full Text PDFAging of disposable face masks in landfill leachate poses cyto-genotoxic risks to Allium cepa: Perils of uncontrolled disposal of medical waste.
Plant Physiol Biochem
January 2025
Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. Electronic address:
The accumulation of disposable face masks (DFMs) has become a significant threat to the environment due to extensive use during the COVID-19 pandemic. In this research, we investigated the degradation of DFMs after their disposal in landfills. We replicated the potential degradation process of DFMs, including exposure to sunlight before subjecting them to synthetic landfill leachate (LL).
View Article and Find Full Text PDFA repercussion of COVID-19 lockdown on water quality along the east coast of India.
Environ Sci Pollut Res Int
January 2025
Ministry of Earth Sciences, National Centre for Coastal Research, Chennai, 600100, India.
The COVID-19 pandemic and subsequent lockdown measures significantly impacted various sectors, including coastal environments. While restrictions led to temporary improvements in air quality, their effects on coastal waters remained understudy. This research conducted four cruises along the east coast of India during pre- and post-COVID-19 lockdown to assess the water quality changes.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Institute of Human Behaviour and Allied Sciences, Delhi, Delhi, India.
Background: SARS CoV-2, neurotrophic virus in response to neuroinflammation causing varying cognitive deficits in post pandemic period. New onset rapidly progressive cognitive decline and deterioration in degenerative dementia has been seen in clinics in recent times. The paradigm shift of presentation of dementia needs detailed evaluation to facilitate further management.
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