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New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants.
Life (Basel)
August 2024
Department of Biochemistry and Pharmacology, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania.
Article Synopsis
- The review discusses phytophotodermatitis, a skin reaction caused by certain plants when combined with UV light, detailing how specific compounds like furanocoumarins and psoralens lead to skin damage.
- It highlights recent advancements in understanding the skin's response mechanisms and identifies common phototoxic plant families and species, which help in recognizing risks associated with these plants.
- The review also covers diagnostic methods like patch testing and preventive measures such as wearing protective clothing, along with treatment options that have emerged from current research findings.
The bradykinin-forming cascade in anaphylaxis and ACE-inhibitor induced angioedema/airway obstruction.
Front Allergy
January 2024
Division of Pulmonary and Critical Care Medicine, The Medical University of South Carolina, Charleston, SC, United States.
Article Synopsis
- Anaphylaxis is a serious allergic reaction that affects multiple body systems, usually the skin, lungs, heart, and gastrointestinal tract, and can cause severe symptoms like shock or airway obstruction.
- There are two types of triggers: immunologic, which involves the binding of foreign antigens to IgE on mast cells and basophils, and non-immunologic, which can occur through various mechanisms including direct activation of mast cells or immune complex activation.
- The report highlights the role of the bradykinin-forming cascade in severe anaphylaxis symptoms and discusses how disruptions in bradykinin metabolism can contribute to airway obstruction and significant complications.
A Case of COVID-19 Pregnancy Complicated with Hydrops Fetalis and Intrauterine Death.
Medicina (Kaunas)
June 2021
Department of Neonatology, "Victor Babeş" University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timişoara, Romania.
Coronavirus disease 2019 (COVID-19) has rapidly evolved into a worldwide pandemic causing a serious global public health problem. The risk of vertical transmission of SARS-CoV-2 is still debated, and the consequences of this virus on pregnant women and their fetuses remain unknown. We report a case of pregnancy complicated with hydrops fetalis that developed 7 weeks after recovery from a mild SARS-CoV-2 infection, leading to intrauterine death of the foetus.
View Article and Find Full Text PDFBlood-transfusion-related posterior reversible encephalopathy syndrome - A description of a new case and review of the literature.
Brain Circ
December 2020
Department of Radiology, Clara Swain Mission Hospital JV, Bareilly, Uttar Pradesh, India.
Posterior reversible encephalopathy syndrome (PRES) is a neurological syndrome associated with headache, altered mental status, seizures, and visual disturbances and characterized by white matter vasogenic edema affecting predominantly the posterior occipital and parietal lobes of the brain. Neurological complications of blood transfusion are uncommon, and blood-transfusion-related PRES is seldom reported. We report here one such case of PRES.
View Article and Find Full Text PDFSaikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.
Biochem Pharmacol
February 2018
School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, China. Electronic address:
Pseudo-allergic reactions-adverse, non-immunologic, anaphylaxis-like sudden onset reactions mediated through an IgE-independent pathway-are activated by various basic compounds and occur at least as frequently as IgE-mediated reactions to drugs. A large family of G protein coupled receptors (Mas-related genes; Mrgprs) is closely related to pseudo-allergies. However, few therapies can directly target pseudo-allergies and related Mrgprs.
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