AI Article Synopsis
- - The largest monkeypox outbreak in West Africa began in Nigeria in September 2017, leading to the first human cases being reported outside Africa when four travelers brought the virus to the UK, Israel, and Singapore.
- - An analysis of epidemiological and molecular data revealed that the strains found in the travelers and a Nigerian case shared a recent common ancestor, indicating a possible single source of infection within certain Nigerian states.
- - Findings suggest that the low genetic variation among the exported cases hints at a small, related group of monkeypox isolates as the source, potentially linked to genetic diversity in the monkeypox strains circulating in Bayelsa, Delta, and Rivers states.
Article Abstract
Background: The largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa.
Methods: Epidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak.
Results: Isolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers.
Conclusions: Monophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016419 | PMC |
| http://dx.doi.org/10.1093/infdis/jiaa559 | DOI Listing |
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