AI Article Synopsis
- Fourier transform infrared (FTIR) microspectroscopy is used to analyze biochemical changes in 143B osteosarcoma cells after treatment with polymeric invertible micellar assemblies (IMAs) and curcumin-loaded IMAs.
- Principal component analysis (PCA) was applied to the FTIR data, highlighting significant differences in the chemical structures of treated versus untreated cells, particularly in the fingerprint region of 1480-900 cm.
- The study demonstrates that combining FTIR microspectroscopy with PCA is effective for understanding how osteosarcoma cells interact with drug-loaded polymer micelles.
Article Abstract
Fourier transform infrared (FTIR) microspectroscopy provides a biochemical fingerprint of the cells. In this study, chemical changes in 143B osteosarcoma cells were investigated using FTIR analysis of cancer cells after their treatment with polymeric invertible micellar assemblies (IMAs) and curcumin-loaded IMAs and compared with untreated osteosarcoma cells. A comprehensive principal component analysis (PCA) was applied to analyze the FTIR results and confirm noticeable changes in cell surface chemical structures in the fingerprint regions of 1480-900 cm. The performed clustering shows visible differences for all investigated groups of cancer cells. It is demonstrated that a combination of FTIR microspectroscopy with PCA can be an efficient approach in determining interactions of osteosarcoma cells and drug-loaded polymer micellar assemblies. Graphical abstract.
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| http://dx.doi.org/10.1007/s00216-020-02858-4 | DOI Listing |
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