Unlabelled: In recent years there has been a lot of talk about toothpastes with a particular chemical compound: stannous fluoride (SnF). Its presence is currently still highly controversial, as the latter could have negative health effects. The different companies that produce toothpastes express its dosage in ppm. The purpose of this systematic literature review is to analyze all randomized clinical trials in the literature over the last 10 years and to draw clear results on the function of stannous fluoride, for this purpose the authors performed a Mann-Whitney Test.
Materials: The first analysis of the literature produced a number greater than 800 results, subsequently applying the inclusion and exclusion criteria, and following a manual analysis of the results, 26 manuscripts have been obtained.
Results: From the results analyzed in this review, it could be shown that stannous fluoride does not present important contraindications, if not those commonly reported for fluorine. A meta-analysis on enamel loss has been conducted, it shows that SnF products provide better results with a < 0.05 value.
Conclusion: This compound could have significant effects in favor of erosion and recalcification of the enamel, on the biofilm formation, gingival inflammation, and in addition, it could be an important aid in the removal of tooth stains and halitosis.
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http://dx.doi.org/10.3390/biomimetics5030041 | DOI Listing |
Microorganisms
December 2024
Oral Care Product Development, The Procter & Gamble Company, Cincinnati, OH 45202, USA.
Various ingredients are utilized to inhibit the growth of harmful bacteria associated with cavities, gum disease, and bad breath. However, the precise mechanisms by which these ingredients affect the oral microbiome have not been fully understood at the molecular level. To elucidate the molecular mechanisms, a high-throughput bacterial transcriptomics study was conducted, and the gene expression profiles of six common oral bacteria, including two Gram-positive bacteria (, ) and four Gram-negative bacteria (, , , and ), were analyzed.
View Article and Find Full Text PDFClin Oral Investig
December 2024
Department of Pedodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.
Objectives: This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.
Materials And Methods: Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P-4 peptide (Curodont-Repair), stannous/Sn containing solution (8% Sn), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn+Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)]. Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day.
Biosens Bioelectron
March 2025
School of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin, 300072, China.
Biomarker detection has emerged as an essential complementary approach for early-stage screening of tumors. Conventional methods are constrained by bulky systems, cumbersome operation steps, and low detection accuracy. Here, we demonstrate a dual-resonance optimally configured lossy mode resonance (LMR) immunoprobe for detecting prostate-specific antigen (PSA), a biomarker for prostate cancer (PCa).
View Article and Find Full Text PDFCompend Contin Educ Dent
November 2024
Director Clinical Research, Colgate-Palmolive Co., Piscataway, New Jersey.
Background: This study compared the extrinsic tooth stain removal efficacy of a 0.454% stannous fluoride dentifrice stabilized with nitrate and phosphates (SNaP) versus a non-whitening regular fluoride dentifrice (negative control) after 3 and 6 weeks of product use.
Methods: This phase III, double-blind, randomized, two-cell, parallel-group study was conducted on 80 healthy adults in Puerto Rico.
Compend Contin Educ Dent
November 2024
Senior Vice President and Distinguished Fellow, Clinical Research, Colgate-Palmolive Co., Piscataway, New Jersey.
Background: Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily.
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