We introduce a 20-year-old patient, with prior diagnosis of ataxia-telangiectasia syndrome, urgently assesed because of an upper gastrointestinal bleeding, identifying in the urgent endoscopy an intestinal-type gastric adenocarcinoma as its origin.
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http://dx.doi.org/10.17235/reed.2020.6922/2020 | DOI Listing |
Clin Transl Gastroenterol
March 2025
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine.
Background: Helicobacter pylori (Hp) and gastric atrophy represent significant risk factors for gastric cancer. Nevertheless, to date no nomogram has been developed to predict gastric cancer based on the specific combination of risk factors, present in individual cases.
Methods: A retrospective-cohort study was conducted using health-screening data collected between 2003 and 2018.
Background/aim: TNM stage is crucial for patients with gastric cancer because curative resection and treatment are only possible in early TNM stages. Therefore, our objective was to assess the association of clinicopathological features with TNM stage in such patients.
Patients And Methods: The association of age, sex, tumor location and Lauren type with TNM stage was analyzed in 910 patients with gastric cancer.
Genome Med
February 2025
Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Zefat, Israel.
Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for gastric cancer (GC) development. A growing body of evidence suggests a causal link between infection with H.
View Article and Find Full Text PDFEur J Gastroenterol Hepatol
December 2024
Department of Gastroenterology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Gastric intestinal metaplasia (GIM) is a pathological process where gastric mucosal epithelial cells are replaced by intestinal-type cells, serving as a precursor lesion for gastric cancer. This transformation involves various genetic and environmental factors, affecting key genes and signaling pathways. Recent research has revealed complex mechanisms, including changes in gene expression, abnormal signaling pathway activation, and altered cell behavior.
View Article and Find Full Text PDFGastric Cancer
February 2025
Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
Background: Within the tumor microenvironment (TME), the association of B lymphocytes (B cells) with prognosis and therapy response in gastric cancer (GC) remains poorly characterized. We investigated the predictive and prognostic value of B cells, including their spatial organization within the TME, in one of the largest multi-cohort studies to date.
Methods: Using CD20 immunohistochemistry, we evaluated B cell density in resection specimens from 977 patients with resectable GC across three cohorts, including the randomized phase III Korean CLASSIC trial.
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