The degradation of two organophosphates, chlorpyrifos and diazinon, in water using microplasma equipment to produce ozone and the identification of their products were studied by using liquid chromatography-mass spectrometry. The organophosphates gradually decreased with time and were completely removed after 10 min, and diazinon was degraded at a relatively fast rate compared to chlorpyrifos. The products formed during the process were identified and determined with accurate mass measurements and tandem mass spectrometry spectra, providing reliable structural determination. Chlorpyrifos oxon was formed through the oxidation of chlorpyrifos, followed by the formation of 3,5,6-trichloro-2-pyridinol and diethyl phosphate by hydrolysis. Diazinon formed various products through more complicated degradation processes than those of chlorpyrifos. The major products of diazinon degradation were 2-isopropyl-6-methyl-4-pyrimidinol and diethyl phosphate by hydrolysis after oxidation, exhibiting diazoxon as an intermediate at trace levels. Direct hydrolysis of diazinon also occurred, producing diethyl thiophosphate, which was observed at a low concentration for a transient time and exhibited a less favorable process than sequential oxidation and hydrolysis. The other products, hydroxy diazinons and hydroxy-2-isopropyl-6-methyl-4-pyrimidinols, formed by hydroxylation, were also identified, but they were present in low amounts. Degradation mechanisms of chlorpyrifos and diazinon were proposed with the quantitatively evaluated products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jssc.202000584 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust.
Environ Int
November 2024
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Objective: Elevated pesticide concentrations have been found in dust from homes with residents who use agricultural pesticides, but few studies have compared these concentrations to quantitative measures of their use. We evaluated household pesticide dust concentrations in relation to quantitative, active ingredient-specific metrics of agricultural pesticide use in the Biomarkers of Exposure and Effect in Agriculture Study.
Methods: Participants provided vacuum dust samples (2013-2018) and information regarding recent (last 12 months) and lifetime pesticide use.
Evaluation of cumulative exposures to multiple pesticide residues in three characteristic fruits in the Northwest of Iran: a risk assessment using Monte Carlo Simulation.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
This study was conducted to monitor and evaluate the health risks of multiple organophosphorus pesticide residues in three characteristic fruits of Maragheh district, East Azerbaijan province. The Monte Carlo method was used to quantify the possible non-carcinogenic health risks associated with pesticide residues in adults and children. The residues of 17 pesticides in 36 samples were analysed using the QuEChERS extraction method coupled with gas chromatography-mass spectrometry (GC/MS).
View Article and Find Full Text PDFPlasma pesticide residues-serum 8-OHdG among farmers/non-farmers diagnosed with lymphoma, leukaemia and breast cancers: A case-control study.
PLoS One
October 2024
ICMR-National Institute of Nutrition, Tarnaka, Osmania University, Hyderabad, Telangana, India.
Article Synopsis
- A hospital-based study in Hyderabad, India examined the link between pesticide exposure and the levels of a cancer-associated biomarker (8-OHdG) in farmers and non-farmers with different types of cancers.
- The research revealed that farmers with leukemia had higher pesticide residue levels in their blood compared to those with lymphoma and breast cancer, while non-farmers and healthy individuals showed no such residues.
- The findings highlighted a significant correlation between one specific pesticide (profenofos) and elevated 8-OHdG levels, indicating a need for further research to explore these associations in larger groups.
A reliable quantification of organophosphorus pesticides in brown rice samples for proficiency testing using Japanese official analytical method, QuEChERS, and modified QuEChERS combined with isotope dilution mass spectrometry.
J Pestic Sci
August 2024
Hatano Research Institute (HRI), Food and Drug Safety Center (FDSC).
The objective of the present study is to provide reliable concentration values as assigned values for target pesticides in brown rice samples used in proficiency testing (PT) organized by the Hatano Research Institute (HRI). The test samples for PT were prepared by immersing brown rice in the pesticide solution and using a spray dryer by the HRI. Homogeneity and stability assessments were performed for PT samples, and the relative uncertainties due to inhomogeneity and instability were 0.
View Article and Find Full Text PDFDevelopment of a Generic Physiologically Based Kinetic Model for the Prediction of Internal Exposure to Organophosphate Pesticides.
Environ Sci Technol
October 2024
Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.
Article Synopsis
- The study explores the development of a generic physiologically based kinetic (PBK) model for assessing the effects of organophosphate (OP) pesticides on both rats and humans.
- It utilizes data from existing studies and quantitative structure property relationships to evaluate how well the model predicts the absorption and toxicity of various OP compounds, showing high accuracy in most cases.
- The findings suggest this PBK model can be a valuable tool for next generation risk assessment (NGRA) of OP pesticides and potentially be adapted for other chemical classes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!