The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure-Activity Relationship (QSAR) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross-cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an micronucleus assay performed with triazine amine would be needed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447991 | PMC |
| http://dx.doi.org/10.2903/j.efsa.2020.6053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The carbon dioxide (CO) capture and utilization strategy has emerged as an innovative and multifaceted approach to counteract carbon emissions. In this study, a highly porous muffin polyhedral barium (Ba) ̵ organic framework (BaTATB; HTATB = 4,4',4″--triazine-2,4,6-triyl-tribenzoic acid) was synthesized solvothermally. The three-dimensional honeycomb pore architectures were densely populated with Lewis acidic Ba(II) metal sites and basic nitrogen-rich triazines.
View Article and Find Full Text PDFPyrimido[5,4-]azolo[1,5-]pyrimidines and pyrimido[4,5-][1,2,4]triazolo[5,1-][1,2,4]triazines: multi-component synthesis and cytotoxic activity.
Org Biomol Chem
January 2025
Ural Federal University named after the First President of Russia B.N. Eltsin, Mira st. 19, Yekaterinburg, 620002, Russian Federation.
A multi-component method for the synthesis of pyrimido[5,4-]azolo[1,5-]pyrimidines and pyrimido[4,5-][1,2,4]triazolo[5,1-][1,2,4]triazines has been developed. It was shown that vicinal amino-nitrile and amino-ethoxycarbonyl derivatives of azolo[1,5-]pyrimidines and azolo[5,1-][1,2,4]triazines were converted to tricyclic heterocycles in the "AcOH-RC(OEt)-amine" system. Reaction conditions were optimized, patterns of this process were investigated, and intermediates were isolated.
View Article and Find Full Text PDFDonor-acceptor conjugated porous polymers from truxene and triazine: Effect of connecting units on photocatalytic activity for selective oxidation of amines and sulfides.
J Colloid Interface Sci
December 2024
College of Chemistry and Chemical Engineering, Taishan University, Taian 271000, China. Electronic address:
Donor-acceptor (D-A) conjugated polymers have been widely reported as promising photocatalysts for organic conversion. However, achieving excellent photocatalytic performance still relies on the rational design of molecular structures and the careful selection of appropriate building blocks. In this study, we designed two D-A type conjugated porous polymers (CPPs) using 2,7,12-tribromo-5,5,10,10,15,15-hexamethyl-10,15-dihydro-5H-diindeno[1,2-a:1',2'-c]fluorene (Tx) as the donor unit and two 1,3,5-triazine-based derivatives, namely 2,4,6-tri(thiophen-2-yl)-1,3,5-triazine (TTT) and 2,4,6-triphenyl-1,3,5-triazine (TPT), as the acceptor units.
View Article and Find Full Text PDFConstructing an Isopolymolybdate-Based Bifunctional Photocatalyst for Promoting Nitroaromatic Reduction and C-H Oxidation.
Inorg Chem
January 2025
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Amide compounds are widely present in drug molecules and natural products, which can be synthesized by acid-amine condensation. It is urgent to design new photocatalysts for achieving both nitroaromatic reduction and C-H oxidation to obtain raw materials, carboxylic acids, and aromatic amines. Herein, a novel isopolymolybdate-incorporated photoactive metal-organic framework, -TPT, was constructed by combining the oxidation catalyst [MoO], Ni(II) cation, and photosensitive ligand 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT).
View Article and Find Full Text PDFTriazine-Functionalized Nitrogen-Rich Covalent Organic Framework as an Electrode Material for Aqueous Symmetric Supercapacitor.
Chem Asian J
December 2024
Department of Chemistry, Dharma Samaj College Aligarh, UP, 202001.
Covalent triazine frameworks, with their ordered pores and crystalline structure that exhibit heteroatom impacts, demonstrate outstanding chemical stability, making them designable for charge storage applications. In this study, the triazine-based covalent organic frameworks (TPT@BDA-COF) was synthesized using 4',4''',4'''''-(1,3,5-Triazine-2,4,6-triyl) tris (([1,1'-biphenyl]-4-amine)) (TPT) and 4,4'-Oxydibenzaldehyde (BDA) following polycondensation process. Interestingly, these resulted in the fabrication of a well-connected, orderly porous crystalline structure, redox-active moiety, and significantly high doping atomic percentages of N (~13.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!