AI Article Synopsis
- Class A2 gestational diabetes mellitus (GDMA2) impacts HDL function and composition in pregnant women, affecting both maternal and fetal health.
- In the study, women with GDMA2 showed decreased levels of apolipoprotein A1 (APOA1) in their plasma, while both APOA1 and paraoxonase1 (PON1) were released more from HDL compared to normal pregnancies.
- Findings suggest that the placenta may play a protective role for the fetus by preserving HDL components, indicating the need for further investigation into these dynamics.
Article Abstract
Class A2 gestational diabetes mellitus (GDMA2) has short- and long-term effects on the mother and child. These may include abnormalities of placentation, damage to endothelial cells and cardiovascular disease. This research investigated the function and composition of high-density lipoproteins (HDL) among women with GDMA2 and their fetuses. Thirty pregnant women were recruited during admission for delivery. The function and expression of HDL, paraoxonase1 (PON1) and apolipoprotein A1 (APOA1) in the blood samples and the placental tissue were evaluated. The effect of HDL on migration of endothelial cells was measured in vitro. Compared to normal pregnancy (NP), APOA1 in the maternal plasma of women with GDMA2 was decreased. More APOA1 and PON1 were released from HDL of women with GDMA2, compared to NP. Placental APOA1 and PON1 were decreased in GDMA2. For endothelial cells stimulated with TNFα, HDL cell migration was decreased when cells were evaluated with NP-HDL, as compared to GDMA2-HDL. GDMA2 affects the composition and function of HDL in plasma. Changes in HDL commonly seen in GDMA2 were observed in maternal and placental samples, but not in cord samples. These results might indicate a placental role in protecting the fetus by preserving the components and functions of HDL and require further investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504441 | PMC |
| http://dx.doi.org/10.3390/ijms21176281 | DOI Listing |
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