Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (-), possessing 3--sulfonato, 56 epoxy (or 5(6)-dehydro), and 4,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Their structures were determined by NMR and MS methods. The compounds , and inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551063 | PMC |
| http://dx.doi.org/10.3390/md18090454 | DOI Listing |
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Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge .
Mar Drugs
August 2020
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (-), possessing 3--sulfonato, 56 epoxy (or 5(6)-dehydro), and 4,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Their structures were determined by NMR and MS methods. The compounds , and inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.
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