Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jns.2020.117104 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation.
Inflammation
January 2025
Department of Respiratory Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, China.
Macrophages exhibit diverse phenotypes depending on environment status, which contribute to physiological and pathological processes of immunological diseases, including sepsis, asthma, multiple sclerosis and colitis. The alternative activation of macrophages is tightly regulated to avoid excessive activation and damage of tissues and organs. Certain works characterized that succinate dehydrogenase (SDH) altered function of macrophages and promoted inflammatory response in M1 macrophages via mitochondrial reactive oxygen species (ROS).
View Article and Find Full Text PDFTargeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice.
Nutrients
December 2024
Institute for Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Background/objectives: The extracellular calcium-sensing receptor (CaSR) is a multifunctional receptor proposed as a possible drug target for inflammatory bowel disease. We showed previously that CaSR inhibition with NPS 2143, a negative allosteric modulator of the CaSR, somewhat ameliorated the symptoms of chemically induced severe colitis in mice. However, it was unclear whether the potential of CaSR inhibition to reduce colitis may have been overshadowed by the severity of the induced inflammation in our previous study.
View Article and Find Full Text PDFEffect of Particulate Matter 2.5 on Primary Gingival Keratinocyte and Human Gingival Fibroblast Cell Lines.
Eur J Dent
December 2024
Department of Oral Biology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Objective: Particulate matter 2.5 (PM2.5), an important air pollution particle, has been previously studied for its effects on various normal and cancer tissues.
View Article and Find Full Text PDFNetwork pharmacology integrated with molecular docking and molecular dynamics simulations to explore the mechanism of Shaoyao Gancao Tang in the treatment of asthma and irritable bowel syndrome.
Medicine (Baltimore)
December 2024
Department of Warm Disease, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Background: Numerous studies have demonstrated a correlation between asthma and irritable bowel syndrome (IBS). The Chinese herbal compound Shaoyao Gancao Tang (SYGCT) has been found to have therapeutic effects on both asthma and IBS, but the underlying mechanisms are not yet fully understood. This study aims to explore the key components, key targets, and potential mechanisms of SYGCT in treating asthma with IBS by using network pharmacology, molecular docking techniques and molecular dynamics simulation.
View Article and Find Full Text PDFDeep silicification-assisted long-term preservation of structural and genomic information across biospecies: From micro to macro.
Proc Natl Acad Sci U S A
October 2024
MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, People's Republic of China.
Article Synopsis
- Effective preservation of biological samples requires maintaining their morphology, structure, and genomic attributes, but current methods struggle to achieve this simultaneously.* -
- The new "deep silicification" method, inspired by fossilization, operates at room temperature and improves silica penetration in organisms, enhancing their structural integrity without the need for cold storage.* -
- This innovative approach shows a remarkable increase in genomic storage longevity and near-perfect fidelity in whole-genome sequencing, suggesting a major advancement in how biological samples can be preserved.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!