AI Article Synopsis
- The study focuses on laryngeal dysplasia, a precancerous condition of the larynx, examining the role of reflux in its development.
- Researchers analyzed tissue samples from patients who had surgery for laryngeal dysplasia, measuring levels of pepsin, enterokinase, and bilirubin using immunohistochemical methods.
- Findings indicate a potential correlation between reflux indicators and laryngeal dysplasia, suggesting that more extensive studies are needed to firmly establish reflux as a risk factor for laryngeal cancer.
Article Abstract
Objectives: Laryngeal dysplasia (LD) is a precancerous lesion of the larynx. In this study, the laryngeal tissue of patients with laryngeal dysplasia was taken as the research object, and the aetiology of reflux was analysed.
Method: Patients with laryngeal dysplasia after surgery were selected as our subjects. The levels of pepsin, enterokinase and bilirubin in laryngeal tissue samples of the two groups were detected by immunohistochemical method.
Results: The OR values (95% CI) of pepsin, enterokinase and bilirubin were 0.67 (0.19-2.36), 0.80 (0.22-2.98) and 1.33 (0.30-5.96), respectively, in the univariate analysis. Besides, in the multivariate analysis, the OR values (95% CI) of pepsin, enterokinase and bilirubin were 0.57 (0.14-2.30), 0.73 (0.18-2.92) and 1.40 (0.30-6.53), respectively.
Conclusion: Larger sample size should be applied to prospective studies on whether reflux is a risk factor for laryngeal cancer.
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| http://dx.doi.org/10.1111/coa.13638 | DOI Listing |
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