AI Article Synopsis
- This study explores the impact of anti-osteoporotic agents, teriparatide and bisphosphonate, on spinal fusion surgery outcomes.
- Eight randomized clinical trials and three prospective studies involving 676 patients were assessed to compare fusion rates and the effectiveness of treatments.
- Results indicated that teriparatide combined with Denosumab significantly improved fusion rates compared to placebo and bisphosphonate, suggesting teriparatide is a beneficial option for spinal fusion procedures.
Article Abstract
Background: Giving patients anti-osteoporotic agents peri-operatively is a well-accepted strategy to increase fusion rate and prevent complications. The purpose of this study was to investigate effectiveness of teriparatide and bisphosphonate on fusion surgery of thoracic and lumbar spine.
Methods: We searched EMBASE and PubMed for randomized clinical trials (RCTs) and prospective comparative studies using teriparatide or bisphosphonate in peri-operative spinal fusion surgery. Our synthesized data of fusion rate, Oswestry disability index (ODI), and adverse event in contrast-based network meta-analysis. Pooled results were presented in risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI).
Results: Our search hit eight RCTs and three prospective studies with 676 patients receiving spinal surgery. Pooled result showed that teriparatide+Denosumab leads to significantly higher fusion rate than placebo (RR, 2.84; 95% CI: 1.22 to 6.60) and bisphosphonate (RR, 2.59; 95% CI: 1.13 to 5.96). We did not observe significant finding among placebo, teriparatide, and bisphosphonate in the two network models.
Conclusion: This is the first network meta-analysis providing an overview of the use of teriparatide and bisphosphonate for spinal fusion surgery. Teriparatide treatments are worth to be consider for spinal fusion surgery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462270 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237566 | PLOS |
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