We propose a simple, highly scalable, and very efficient scheme for coherent combining of tiled aperture arrays. The scheme relies on changing the beam phasing paradigm from the commonly used in-phase pattern to the out-of-phase pattern (interleaved 0/ phases in the neighboring channels) and using an additional simple combining stage (a beamsplitter). In a proof-of-concept experiment with a one-dimensional fiber array, we achieved 89% of the power in the main combined beam. In numerical modeling, we found optimal conditions leading to 98% efficiency for an unlimited number of channels and arbitrary small initial aperture fill factors. The scheme is highly resistant to the effect of sub-aperture clipping and suitable for combining ultrashort pulses.
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http://dx.doi.org/10.1364/OL.391259 | DOI Listing |
JAMA Oncol
December 2024
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Importance: Only a small fraction of patients with advanced non-small cell lung cancer (NSCLC) respond to immune checkpoint inhibitor (ICI) treatment. For optimal personalized NSCLC care, it is imperative to identify patients who are most likely to benefit from immunotherapy.
Objective: To develop a supervised deep learning-based ICI response prediction method; evaluate its performance alongside other known predictive biomarkers; and assess its association with clinical outcomes in patients with advanced NSCLC.
Arh Hig Rada Toksikol
December 2024
1University of Rijeka Faculty of Medicine, Department of Microbiology and Parasitology, Rijeka, Croatia.
Environmental contamination with biofilm can be a source of healthcare-associated infections. Disinfection with various biocidal active substances is usually the method of choice to remove contamination with biofilm. In this study we tested 13 different disinfection protocols using gaseous ozone, citric acid, and three working concentrations of benzalkonium chloride-based professional disinfecting products on 24-hour-old biofilms formed by two strains on ceramic tiles.
View Article and Find Full Text PDFCell Rep Med
December 2024
Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, Shenyang 110001, China. Electronic address:
Neoadjuvant chemotherapy assessment is imperative for prognostication and clinical management of locally advanced gastric cancer. We propose an incremental supervised contrastive learning model (iSCLM), an interpretable artificial intelligence framework integrating pretreatment CT scans and H&E-stained biopsy images, for improved decision-making regarding neoadjuvant chemotherapy. We have constructed and tested iSCLM using retrospective data from 2,387 patients across 10 medical centers and evaluated its discriminative ability in a prospective cohort (132 patients; ChiCTR2300068917).
View Article and Find Full Text PDFChem Commun (Camb)
December 2024
Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Coordination networks based on lanthanide ions entangle collective magnetic phenomena, otherwise only observed in inorganic 4f materials, and the tunable spatial and electronic structure engineering intrinsic to coordination chemistry. In this review, we discuss the use of 2D-structure-directing linear {LnI} nodes to direct the formation of polymeric coordination networks. The equatorial coordination plasticity of {LnI} results in broad structural diversity, including previously unobtainable tessellations containing motifs observed in quasicrystalline tilings.
View Article and Find Full Text PDFThe tiled fiber laser array is a promising architecture for power scaling and mitigation of atmospheric turbulence. Precise tip-tilt detection and steering of the beamlets in the array to guarantee effective overlap in the far-field is essential for high beam qualities. However, the beamlets are tightly coupled in the far-field, making it a major challenge to identify each other.
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