In the present paper the possibility of an energetic self-optimization as a consequence of thermodynamic stability is addressed. This feature is analyzed in a low dissipation refrigerator working in an optimized trade-off regime (the so-called Omega function). The relaxation after a perturbation around the stable point indicates that stability is linked to trajectories in which the thermodynamic performance is improved. Furthermore, a limited control over the system is analyzed through consecutive external random perturbations. The statistics over many cycles corroborates the preference for a better thermodynamic performance. Endoreversible and irreversible behaviors play a relevant role in the relaxation trajectories (as well as in the statistical performance of many cycles experiencing random perturbations). A multi-objective optimization reveals that the well-known endoreversible limit works as an attractor of the system evolution coinciding with the Pareto front, which represents the best energetic compromise among efficiency, entropy generation, cooling power, input power and the Omega function. Meanwhile, near the stable state, performance and stability are dominated by an irreversible behavior.
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http://dx.doi.org/10.1038/s41598-020-71130-7 | DOI Listing |
Trends Biotechnol
March 2025
Tidetron Bioworks Technology (Guangzhou) Co., Ltd, Guangzhou Qianxiang Bioworks Co., Ltd, Guangzhou, Guangdong 510000, PR China. Electronic address:
Targeted random mutagenesis is crucial for breeding, directed evolution, and gene function studies, yet efficient tools remain scarce. Here, we present obligate mobile element guided activity (OMEGA)-R, an innovative targeted random mutagenesis system that integrates SpyCatcher-enIscB and PolI3M-TBD-SpyTag, outperforming existing state-of-the-art technologies in key metrics, such as protein size, mutagenesis efficiency, window length, and continuity. OMEGA-R achieves a dramatic enhancement of on-target mutagenesis, reaching a rate of 1.
View Article and Find Full Text PDFBMJ Ment Health
March 2025
CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Background: The Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS), a questionnaire designed for the assessment of mental well-being, is widely used in different countries and cultures worldwide. However, there is a lack of studies examining its metric performance and measurement invariance across countries.
Objective: This study aims to examine the internal structure, reliability and cross-country validity of the WEMWBS in three European populations.
Clin Nutr ESPEN
March 2025
Xuanwu Hospital, Capital Medical University, Beijing, China; School of Nursing, Capital Medical University, Beijing, China. Electronic address:
Background: Tumors and surgical procedures trigger a series of metabolic responses that put gastric cancer patients at constant risk of malnutrition during the perioperative period. Meanwhile, the effectiveness of enteral immunonutrition (EIN) for these patients remains a subject of ongoing debate.
Objective: This systematic review and evidence map aim to retrieve randomized controlled trials (RCTs) on perioperative EIN interventions in gastric cancer patients undergoing surgery and evaluate their effectiveness.
J Lipid Res
March 2025
LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany. Electronic address:
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain composition. This batch is constantly remodeled by the Lands cycle, a metabolic pathway replacing one chain at the time. Using the alkyne lipid lyso-phosphatidylpropargylcholine (LpPC), a precursor and intermediate in PC synthesis and remodeling, we study both processes in brain endothelial bEND3 cells.
View Article and Find Full Text PDFOmega (Westport)
March 2025
Centre for Mental Health and Community Wellbeing, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Experiencing the death of a loved one is a stressful and disruptive event that can have short-term and long-term detrimental effects on the grief, mental health, and social functioning of the bereaved individuals. Grief camps represent a relatively novel form of support. However, little is known about their effectiveness.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!