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Autologous abdominal fat transplantation for treating complex gastrointestinal fistulas: a promising new approach.
Gastrointest Endosc
October 2024
Gastrointestinal Endoscopy Division, Instituto D´Or de Pesquisa e Ensino, Hospital Vila Nova Star; Gastrointestinal Endoscopy Unit, Department of Gastroenterology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Modern trials are most useful when they are pragmatic and explanatory - there is no continuum.
J Clin Epidemiol
December 2024
Pragmatic Evidence Lab, Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, California, USA. Electronic address:
Background And Objectives: Over half a century ago, the terms "pragmatic" and "explanatory" were introduced to biomedicine by Schwartz and Lellouch, presenting two distinct conceptual approaches to trial design. Today, we frequently say that there are pragmatic trials and there are explanatory trials. Pragmatic trials inform decision-making in practice, and explanatory trials aim to understand the mechanism of an intervention.
View Article and Find Full Text PDFMolecular Markers in the World Health Organization Classification of Head and Neck Tumors, Fifth Edition.
Radiographics
October 2024
From the Departments of Radiology (A.A., A.B., J.M., D.R., P.R.) and Neuroradiology (P.V.), Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224; Department of Radiology, Mayo Clinic, Rochester, Minn (G.B.); and Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (K.V.).
The past decade has seen exponential advancements in molecular markers and the genetics of tumors, recognizing the limitations of conventional histopathology for grading, classification, and prognostication. Such advances have resulted in changes to classification systems, for example, with the incorporation of objective molecular and genetic information into the 2021 World Health Organization (WHO) classification of central nervous system tumors. The fifth edition of the WHO classification of head and neck tumors (HN5) (beta online version, 2022) also introduced major changes based on molecular markers, including additions, deletions, and reclassifications of entities, with the idea of being more objective and standardized.
View Article and Find Full Text PDFWhat matters to you? Public and patient involvement in the design stage of research.
Res Involv Engagem
September 2024
Bournemouth University, Bournemouth, UK.
Background: Public and patient involvement is critical to ensure that research is relevant and addresses what matters most to the person through co-production. Involvement at the design stage where ideas for research are developed prior to formal ethical approval, can positively influence the direction of research design, methods, and outcomes. Although ethical approval is not required at this stage, being ethically conscious is imperative to prevent unwarranted unethical practices.
View Article and Find Full Text PDFBeyond the 5-year recovery mark: Perspectives of researchers with lived and living experience on public engagement and discourse.
Int J Drug Policy
November 2024
Department of Public and Nonprofit Studies, Georgia Southern University, USA. Electronic address:
Article Synopsis
- * The National Council for Mental Wellbeing released guidelines on protecting these individuals in public discussions, but the commentary critiques the recommendation that only those with five or more years of recovery should participate.
- * The authors argue this guideline excludes many valuable voices, including those with recent experiences in the evolving landscape of substance use, and propose more inclusive alternatives for engaging PWLLE in meaningful dialogue.
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