AI Article Synopsis
- A new method was created to efficiently synthesize thiocarbamyl fluorides and isothiocyanates using amines and trifluoromethanesulfonyl chloride.
- The process utilizes triphenylphosphine and sodium iodide as reducing agents, leading to moderate to excellent yields of the desired compounds from primary and secondary amines.
- The method shows versatility with a wide range of substrates and demonstrates good compatibility with different functional groups.
Article Abstract
A practical and efficient method to synthesize thiocarbamyl fluorides and isothiocyanates from amines with trifluoromethanesulfonyl chloride was developed. In the presence of the reducing agent triphenylphosphine and sodium iodide, thiocarbamyl fluorides and isothiocyanates were synthesized from secondary/primary amine in moderate to excellent yields, respectively. A broad scope of substrates and good functional group compatibility were observed.
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| http://dx.doi.org/10.1021/acs.joc.0c01634 | DOI Listing |
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