SARS-Cov2 coinfection with other respiratory viruses is very rare. Adenovirus coinfection is even more unusual. We report the case of a patient with poorly controlled diabetes, and he was admitted to the emergency department because of severe COVID-19 infection. He had unfavorable prognostic factors such as moderate oxygen impairment, positive D-dimer, increased lactate dehydrogenase and ferritin. Adenovirus was isolated in a respiratory viral panel. He developed acute respiratory distress syndrome and required pronation and neuromuscular relaxation in the intensive care unit. Hydroxychloroquine was administered as suggested by the national guidelines. The symptoms resolved, and hospital discharge was indicated. COVID-19 association with another respiratory virus is related with adverse clinical outcomes, such as shock, ventilatory support requirement and greater lymphopenia and thrombocytopenia.
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http://dx.doi.org/10.1016/j.idcr.2020.e00936 | DOI Listing |
Commun Med (Lond)
September 2024
The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Background: Early reports showed that patients with COVID-19 had recrudescence of previously resolved coccidioidomycosis (Valley fever, VF), and there were indications that coinfection had more severe outcomes. We therefore investigated serial infection of Coccidioides posadasii and SARS-CoV-2 in a K18-hACE2 mouse model to assess disease outcomes.
Methods: In our model, we challenged K18-hACE2 mice sequentially with a sub-lethal dose of SARS-CoV-2 and 24 hours later with low virulence strain of Coccidioides posadasii, and vice versa, compared to mice that only received a single infection challenge.
Pediatric Health Med Ther
September 2024
Department of Pharmacy, Tongling Municipal Hospital, Tongling, Anhui, People's Republic of China.
Pediatric Health Med Ther
August 2024
Dunarea de Jos" University of Galati, Faculty of Medicine and Pharmacy, Galati,Romania.
Background: Bacterial pneumonia caused by continues to be one of the most common medical conditions in the pediatric population under 5 years of age, sometimes requiring prolonged hospitalizations and high costs. The time period (3 to 7 days) from the collection of biological samples (ie nasal exudate, pharyngeal exudate, sputum, blood culture and various secretions) to the arrival of the results has been a much discussed issue. Thus, the use of a rapid diagnostic test for urinary antigen, which is easy to use, may lead after the result is known to a targeted therapeutic management and thus to a favorable prognosis of the disease for the patient.
View Article and Find Full Text PDFJ Intensive Care Med
November 2024
Department of Medicine, Division of Genomic Medicine, The George Washington University Medical Center, Washington, DC, USA.
Secondary opportunistic coinfections are a significant contributor to morbidity and mortality in intensive care unit (ICU) patients, but can be difficult to identify. Presently, new blood RNA biomarkers were tested in ICU patients to diagnose viral, bacterial, and biofilm coinfections. COVID-19 ICU patients had whole blood drawn in RNA preservative and stored at -80°C.
View Article and Find Full Text PDFNew Microbiol
May 2024
Microbiology and Virology Unit, "Annunziata" Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy.
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