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Application of adoptive cell therapy in malignant melanoma.
J Transl Med
January 2025
Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity.
View Article and Find Full Text PDFImmune evasion through mitochondrial transfer in the tumour microenvironment.
Nature
January 2025
Division of Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan.
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses. However, detailed mechanisms of such processes remain unclear.
View Article and Find Full Text PDFEXPRESSION EVALUATED BY DIGITAL IMAGE ANALYSIS TECHNIQUES OF PRAME MORE THAN MCM6 IS ASSOCIATED WITH POOR PROGNOSIS IN NEUROBLASTOMA: A PILOT STUDY WITH 84 CASES.
Hum Pathol
January 2025
Département de Biopathologie CHRU-ICL, CHRU Nancy, Vandoeuvre-lès-Nancy, France; INSERM, U1256, NGERE - University of Lorraine, Vandoeuvre-lès-Nancy, France. Electronic address:
Neuroblastoma is a common childhood tumor originating from neural crest progenitors with variable clinical behavior. Despite improved overall survival, factors such as stage, histoprognosis, MYCN status, and age still influence outcome. MCM6 regulates DNA replication and contributes to cancer progression.
View Article and Find Full Text PDFOcular invasion in sinonasal malignant melanoma: A case report and review of literature.
Int J Surg Case Rep
January 2025
Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Background: Sinonasal mucosal melanoma (SNMM) is a rare and aggressive malignancy associated a poor prognosis, prognosis. It is by delayed presentation and nonspecific symptoms. The incidence of SNMM is low, with and there are challenges in achieving local control and managing distant metastases.
View Article and Find Full Text PDFStroke associated with microvascular tumoral infiltration in a patient with metastatic breast cancer.
Radiol Case Rep
March 2025
Maimonides Medical Center, Department of Radiology 4802 10th Avenue, Brooklyn, NY 11219, USA.
Leptomeningeal carcinomatosis is a form of advanced metastatic disease conferring poor prognosis, most commonly associated with melanoma, small cell lung cancer, and breast cancer. In rare cases it has been shown to be associated with stroke thought to be related to vasculopathy caused by tumoral infiltration of cerebral vasculature. We present a case of acute cerebellar infarction in a patient with metastatic breast cancer complicated by leptomeningeal carcinomatosis, admitted for worsening metastatic disease.
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