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| http://dx.doi.org/10.4103/1673-5374.290894 | DOI Listing |
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Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma.
Chem Biol Interact
January 2025
Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science College, Kuvempu University, Shivamogga, 577203, Karnataka, India. Electronic address:
Article Synopsis
- Metastasis is a complicated disease that relies on specific protein interactions, such as Vimentin and NEDD9, which are crucial for cancer progression and treatment resistance.
- Withaferin A (WFA) is a natural compound thought to target Vimentin, potentially offering a way to inhibit metastasis, although its complete mechanism is still not clear.
- Research has utilized various techniques, including gene expression analysis and protein interaction assays, to demonstrate that targeting the Vimentin-NEDD9 interaction with WFA can reduce melanoma spread to the lungs, highlighting its potential as a therapeutic approach.
Withaferin A decreases glycolytic reprogramming in breast cancer.
Sci Rep
October 2024
Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi, 110025, India.
Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism.
View Article and Find Full Text PDFDevelopment, characterization, and evaluation of withaferin-A and artesunate-loaded pH-responsive acetal-dextran polymeric nanoparticles for the management of malaria.
Int J Biol Macromol
July 2024
Department of Herbal Nanotechnology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India. Electronic address:
Artemisinin and its derivatives have been commonly used to treat malaria. However, the emergence of resistance against artemisinin derivatives has posed a critical challenge in malaria management. In the present study, we have proposed a combinatorial approach, utilizing pH-responsive acetal-dextran nanoparticles (Ac-Dex NPs) as carriers for the delivery of withaferin-A (WS-3) and artesunate (Art) to improve treatment efficacy of malaria.
View Article and Find Full Text PDFNovel drug targets and molecular mechanisms for sarcopenia based on systems biology.
Biomed Pharmacother
July 2024
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, UK; Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm SE-17165, Sweden. Electronic address:
Sarcopenia is a major public health concern among older adults, leading to disabilities, falls, fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of sarcopenia and identify potential therapeutic targets using systems biology approaches. RNA-seq data from muscle biopsies of 24 sarcopenic and 29 healthy individuals from a previous cohort were analysed.
View Article and Find Full Text PDFWithaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells.
Phytomedicine
June 2024
Municipal Hospital Affiliated to Taizhou University, Taizhou, Jiaojiang 318000, Zhejiang, China. Electronic address:
Background: Sorafenib (Sora), a multi-target tyrosine kinase inhibitor, is widely recognized as a standard chemotherapy treatment for advanced hepatocellular carcinoma (HCC). However, drug resistance mechanisms hinder its anticancer efficacy. Derived from Withania somnifera, Withaferin A (WA) exhibits remarkable anti-tumor properties as a natural bioactive compound.
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