Seizures are common in veterinary patients and control is critical to the overall patient health. The benzodiazepine class of drugs (diazepam, midazolam, and lorazepam) often are the drug class of choice; however, levetiracetam and propofol also have been gaining favor as anticonvulsant drugs for acute seizure management. After cessation of seizures, practitioners then can discuss long-term seizure control on a case-by-case basis with clients.
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[Teratovigilance. Antiepileptics during pregnancy and paternal use].
Rev Med Suisse
January 2025
Swiss Teratogen Information Service, Service de pharmacologie clinique, Département de médecine, Centre hospitalier universitaire vaudois, 1011 Lausanne.
The 2023-2024 updates on teratovigilance, with a focus on antiseizure medications, highlight several key points. American medical societies have revised their recommendations: maintaining effective seizure control is essential for both maternal and fetal health; lamotrigine, levetiracetam, and oxcarbazepine are preferred first-line treatments, whereas valproic acid and topiramate should be avoided if possible. In March 2024, an update on topiramate indicated an increased risk of neurodevelopmental disorders with prenatal exposure.
View Article and Find Full Text PDFNurses' knowledge to identify, prevent and manage hypertensive disorder of pregnancy.
S Afr Fam Pract (2004)
November 2024
Department of Obstetrics and Gynecology, College of Health Sciences, University of KwaZulu-Natal, Durban.
Background: Hypertensive disorders of pregnancy are major contributors to maternal mortality in South Africa. Preventative strategies in low- and middle-income countries emphasise frequent antenatal visits, symptom identification, patient education and the prophylactic use of calcium and low-dose aspirin to prevent HDP for nurses because they are the frontline workers at antenatal clinics countrywide.
Methods: This was a cross-sectional study where a self-administered questionnaire was conducted among nurses (midwives and professional nurses) employed at hospitals and clinics in Durban, South Africa, to assess their understanding and practices regarding identification and initial management of HDP, particularly for eclampsia and PE with severe features.
Using Cannabis and CBD to Sleep: An Updated Review.
Curr Psychiatry Rep
December 2024
Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, Macquarie University, Sydney, New South Wales, Australia.
Article Synopsis
- The review examines the use of cannabis and cannabinoids for treating sleep disorders, noting that many patients prefer drug-based therapies despite a lack of strong evidence regarding their effectiveness and safety.
- After analyzing twenty-one recent studies, the review identifies trends such as the rise of minor cannabinoids, decentralized research methods, and the use of objective measures in trials.
- It emphasizes the urgent need for more rigorous, well-funded clinical trials with longer durations and larger participant groups to provide clearer guidance for clinicians and patients.
Update on Cannabidiol in Drug-Resistant Epilepsy.
Indian J Pediatr
January 2025
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India.
Article Synopsis
- - CBD is emerging as a beneficial treatment for children with drug-resistant epilepsy (DRE), particularly for conditions like Dravet syndrome, Lennox Gastaut syndrome, and Tuberous sclerosis complex, with regulatory approval in multiple countries.
- - Clinical trials indicate that CBD can reduce seizure frequency and improve the quality of life for affected children, with a generally favorable safety profile, though minor side effects like sleepiness and diarrhea may occur.
- - Accessibility and cost remain significant issues, especially in lower-income regions such as India, prompting a discussion on the opportunities and hurdles of integrating CBD into clinical practice while navigating the evolving regulatory environment.
The value of hypothermia as a neuroprotective and antiepileptic strategy in patients with status epilepticus: an update of the literature.
Expert Rev Neurother
January 2025
Intensive Care Unit, Versailles Hospital, Le Chesnay Cedex, France.
Introduction: Status epilepticus represents a significant neurological emergency, with high morbidity and mortality rates. In addition to standard care, the identification of adjuvant strategies is essential to improve the outcome.
Areas Covered: The authors conducted a narrative review to provide an update on the value of hypothermia as an antiseizure and neuroprotective treatment in status epilepticus.
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