Prostaglandins I2(PGI2) and E1(PGE1) (5 X 10(-7) M) reduced by 30% the content of intracellular cholesterol in cultured human aorta smooth muscle cells after 24 hrs of incubation in a medium without fetal calf serum. Total HDL, as well as HDL3 and HDL2b fractions stimulated the effect of prostaglandins on the reduction (by 50%) of cholesterol level.
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