An efficient method is described to radiolabel several biogenic indole derivatives with carbon-14 at high specific activity.
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Lacto-Fermented Fruits and Vegetables: Bioactive Components and Effects on Human Health.
Annu Rev Food Sci Technol
January 2025
1Department of Food Science and Technology, University of California, Davis, Davis, California, USA; email:
Lacto-fermented fruits and vegetables (FVs) such as kimchi, sauerkraut, and fermented olives and nonalcoholic juices have a long history as dietary staples. Herein, the production steps and microbial ecology of lacto-fermented FVs are discussed alongside findings from human and laboratory studies investigating the health benefits of these foods. Lacto-fermented FVs are enriched in bioactive compounds, including lactic and acetic acids, phenolic compounds, amino acid derivatives such as indole-3-lactic acid, phenyl-lactic acid, γ-aminobutyric acid, and bacteriocins, and beneficial live microbes.
View Article and Find Full Text PDFTryptamine accumulates in cheese mainly via the decarboxylation of tryptophan by lactic acid bacteria.
Food Res Int
January 2025
Molecular Microbiology Research Laboratory, Department of Technology and Biotechnology of Dairy Products, Dairy Research Institute (IPLA-CSIC), Villaviciosa 33300, Spain; Molecular Microbiology Research Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Avenida del Hospital Central de Asturias, Oviedo 33005, Spain. Electronic address:
Few microorganisms are known to decarboxylate L-tryptophan, thereby producing tryptamine, a neuromodulator biogenic amine (BA) that can accumulate in cheese. Since lactic acid bacteria (LAB) are largely responsible for the production of other BA in this product, it was hypothesised that they would also be the main agents of tryptamine production. Using a rapid test based on the natural fluorescence of tryptamine, thousands of bacterial isolates from several cheese samples were screened.
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- The study examines how chronic exposure to digoxin affects locomotor activity and brain chemistry in zebrafish.
- Zebrafish were housed in groups and exposed to 2 μM of digoxin for a week, resulting in increased hyperactivity and decreased anxiety in a novel environment test.
- The findings reveal significant changes in brain monoamine levels, indicating that cardiotonic steroids like digoxin can influence neurotransmission, which might have implications for neuropsychiatric conditions.
Vibrational spectra of serotonin by terahertz time domain spectroscopy and DFT simulations.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Department of Physics, Indian Institute of Technology Kharagpur, Kharagpur 721302, India. Electronic address:
Serotonin is an important biogenic monoamine neurotransmitter that has major influences on mental health disorders; its structural and conformational changes have important roles in the biological functions of the human body. The decreased serotonin levels in the human body are majorly attributed to the causes of anxiety, depressive disorders, mood disorders, etc. Therefore, the quantification of serotonin in our bodies is of utmost importance in unearthing the origin of such physiological disorders.
View Article and Find Full Text PDFInfluence of extreme light/dark cycles on monoamine levels, physiological indices, and emotional behaviors in rats.
Chronobiol Int
December 2024
Graduate School of Community and Human Services, Rikkyo University, Saitama, Japan.
Article Synopsis
- Aberrant light/dark cycles from electric light usage can disrupt circadian rhythms, leading to mood disorders, but research on physiological effects is limited.
- An experiment on male Wistar rats showed that long light phases (20L:4D) led to decreased body temperature and activity rhythms, while long dark phases (4L:20D) caused circadian misalignment, both resulting in increased body weight.
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