AI Article Synopsis
- The study focused on creating new nucleoside derivatives by modifying d-ribose, specifically through steps involving oxidative cleavage and fluorination.
- The researchers tested these new compounds for their ability to suppress the growth of two types of breast cancer cells, MCF7 and MDA-MB-231.
- Among the derivatives, only one (19a) demonstrated a slight effect on inhibiting the growth of the MDA-MB-231 cancer cells.
Article Abstract
Truncated 3'-deoxy- 3', 3' difluororibofuranosyl pyrimidine nucleoside derivatives were synthesized from d-ribose via β-apioribo pyrimidine nucleoside intermediates 11a-c. The synthetic approach signifies that truncation at C3' position of apioribose ring of 13a-c by oxidative cleavage of diols with Pb(OAc) and followed by fluorination with DAST as key steps. Cytotoxic evaluation of synthesized truncated nucleoside derivatives 16a-c and 19a-c were tested against MCF7 and MDA-MB-231 breast cancer cell lines. However, only 19a was shown minimal growth suppression activity on MDA-MB-231 cancer cell lines.
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| http://dx.doi.org/10.1016/j.carres.2020.108113 | DOI Listing |
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