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| http://dx.doi.org/10.1016/j.tmaid.2020.101862 | DOI Listing |
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Initial Empirical Antibiotic Treatment in Patients with COVID-19 is Associated with Excess Adverse Drug Reactions without Clinical Benefit.
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Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Türkiye.
Objectives: Empirical antibiotic use is common among hospitalized patients with coronavirus disease-2019 (COVID-19) pneumonia because it is difficult to differentiate it from concurrent bacterial pneumonia. The aim of this study was to determine risk factors for concurrent bacterial community-acquired pneumonia (b-CAP) and the need for initial empirical antibiotic coverage in patients with pulmonary involvement caused by Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection.
Materials And Methods: This prospective observational study was conducted at a tertiary university hospital between March 2020 and April 2021.
Respiratory Virus-Specific and Time-Dependent Interference of Adenovirus Type 2, SARS-CoV-2 and Influenza Virus H1N1pdm09 During Viral Dual Co-Infection and Superinfection In Vitro.
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December 2024
Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 48, I-50134 Florence, Italy.
Background: Understanding the interference patterns of respiratory viruses could be important for shedding light on potential strategies to combat these human infectious agents.
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The BioArte Ltd., Life Science Park, Triq San Giljan, 3000 San Gwann, Malta.
The human respiratory tract is colonized by a complex microbial community that helps maintain respiratory health and plays a crucial role in defending the host from infections. Respiratory viruses have been demonstrated to alter microbiota composition, resulting in opportunistic species expansion, and increasing the disease severity and host susceptibility to bacterial co-infections. This study aims to examine the compositional differences in the nasal microbiota between SARS-CoV-2-infected and non-infected patients.
View Article and Find Full Text PDFRespiratory Pathogen Coinfection During Intersecting COVID-19 and Influenza Epidemics.
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Respiratory pathogen coinfections pose significant challenges to global public health, particularly regarding the intersecting epidemics of COVID-19 and influenza. This study investigated the incidences of respiratory infectious pathogens in this unique context. We collected throat swab samples from 308 patients with a fever from outpatient and emergency departments at sentinel surveillance hospitals in Xiamen, southeast of China, between April and May 2023, testing for SARS-CoV-2 and 26 other respiratory pathogens.
View Article and Find Full Text PDFColliding Challenges Part 2: An Analysis of SARS-CoV-2 Infection in Patients with Extrapulmonary Tuberculosis Versus SARS-CoV-2 Infection Alone.
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Clinical Hospital for Infectious Diseases and Pneumology "Dr. Victor Babes", 300041 Timisoara, Romania.
: Coinfection with SARS-CoV-2 and extrapulmonary tuberculosis (extraPTB) presents unique clinical challenges due to dual inflammatory responses and potential differences in patient profiles compared to those with SARS-CoV-2 infection alone. This study uniquely contributes to the underexplored interaction between extraPTB and SARS-CoV-2, focusing on systemic inflammation as a critical determinant of outcomes. This retrospective, cross-sectional study included 123 patients aged 19-91 years, hospitalized at Victor Babeș Hospital in Timișoara from March 2020 to March 2022.
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