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In-silico evaluation of the effect of set-up errors on dose delivery during mouse irradiations with a Cs-137 cell irradiator-based collimator system.
Phys Eng Sci Med
January 2025
School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Set-up errors are a problem for pre-clinical irradiators that lack imaging capabilities. The aim of this study was to investigate the impact of the potential set-up errors on the dose distribution for a mouse with a xenographic tumour irradiated with a standard Cs-137 cell irradiator equipped with an in-house lead collimator with 10 mm diameter apertures. The EGSnrc Monte-Carlo (MC) code was used to simulate the potential errors caused by displacements of the mouse in the irradiation setup.
View Article and Find Full Text PDFReduced-dose of bivalirudin (without the post-procedure infusion) in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention.
BMC Cardiovasc Disord
December 2024
State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research Institute, Department of Cardiology, General Hospital of Northern Theater Command, 83 Wenhua Road, Shenyang, Liaoning, 110016, China.
Introduction: In clinical practice, the dose of bivalirudin may not be fully applicable to the Chinese population. Therefore, this study aimed to explore the efficacy and safety of a reduced dose (80% of the recommended dose) of bivalirudin without post-procedure infusion for 3-4 h in patients with acute coronary syndrome (ACS) undergoing elective percutaneous coronary intervention (PCI).
Methods: This was a single-center, retrospective study.
Outcome of osimertinib-treated patients with epidermal growth factor receptor mutation-positive nonsmall cell lung cancer requiring dose reduction: a secondary analysis of the Reiwa study.
Jpn J Clin Oncol
December 2024
Department of Chemotherapy, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.
Background: Osimertinib is effective in patients with epidermal growth factor receptor (EGFR) mutation-positive nonsmall cell lung cancer (NSCLC). However, some patients require osimertinib dose reduction because of adverse events. This study assessed the characteristics of osimertinib dose reduction and compared the efficacies of reduced-dose and regular-dose osimertinib.
View Article and Find Full Text PDFEffect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease.
Eur Radiol
November 2024
Division of Respiratory Medicine and Allergology, Department of Paediatrics, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands.
Background: The assessment of bronchus-artery (BA) metrics on chest CT is important for detecting airway abnormalities. It is less clear how BA metrics are dependent on lung volume.
Methods: CTs were obtained from a COPDGene substudy investigating the impact of radiation dose on lung density.
Evaluation of cross-protection of a reduced-dose PRRS MLV vaccine against the NADC30-like PRRSV challenge.
Front Vet Sci
November 2024
Giantstar Farming & Husbandry Co., Ltd, Chengdu, Sichuan, China.
Introduction: At present, the NADC30-like strain has become the prevalent strain of PRRSV in China. Many studies have found that existing commercial vaccines are ineffective or provide only limited protection. No study has investigated the cross-protection of different dosages of commercial MLV vaccines against NADC30-like PRRSV.
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